Artificial T Cell Adaptor Molecule-Transduced TCR-T Cells Demonstrated Improved Proliferation Only When Transduced in a Higher Intensity

An artificial T cell adaptor molecule (ATAM) was generated to improve persistence of T cell receptor (TCR) gene-transduced T (TCR-T) cells compared to such persistence in a preceding study. ATAMs are gene-modified CD3ζ with the intracellular domain of 4-1BB inserted in the middle of CD3ζ. NY-ESO-1 T...

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Detalles Bibliográficos
Autores principales: Sakai, Toshiyasu, Terakura, Seitaro, Miyao, Kotaro, Okuno, Shingo, Adachi, Yoshitaka, Umemura, Koji, Julamanee, Jakrawadee, Watanabe, Keisuke, Hamana, Hiroshi, Kishi, Hiroyuki, Leitner, Judith, Steinberger, Peter, Nishida, Tetsuya, Murata, Makoto, Kiyoi, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509457/
https://www.ncbi.nlm.nih.gov/pubmed/33005728
http://dx.doi.org/10.1016/j.omto.2020.08.014

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