SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges

Coronavirus disease 2019 (COVID-19) not only causes pulmonary inflammation but also causes multiple organ damages, including the kidney. ACE2, as one of the receptors for SARS-CoV-2 intrusion, is widely distributed in kidney tissues. Currently, the diagnosis and treatment of SARS-CoV-2 infection in...

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Autores principales: Cheng, Yongqian, Wang, Wenling, Wu, Liang, Cai, Guangyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Covid-19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509500/
https://www.ncbi.nlm.nih.gov/pubmed/32984768
http://dx.doi.org/10.1007/s42399-020-00529-0
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author Cheng, Yongqian
Wang, Wenling
Wu, Liang
Cai, Guangyan
author_facet Cheng, Yongqian
Wang, Wenling
Wu, Liang
Cai, Guangyan
author_sort Cheng, Yongqian
collection PubMed
description Coronavirus disease 2019 (COVID-19) not only causes pulmonary inflammation but also causes multiple organ damages, including the kidney. ACE2, as one of the receptors for SARS-CoV-2 intrusion, is widely distributed in kidney tissues. Currently, the diagnosis and treatment of SARS-CoV-2 infection in patients with chronic kidney disease (CKD) are still unclear. Here, we review the recent findings of characteristics of COVID-19 in CKD patients and highlight the possible mechanisms of kidney injury caused by SARS-CoV-2 infection. We then discuss the emerging therapeutic approaches aimed at reducing kidney damage and protecting kidney function including virus removal, immunotherapy, supporting treatment, special blood purification therapy, etc. Problems unresolved and challenges ahead are also discussed.
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spelling pubmed-75095002020-09-23 SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges Cheng, Yongqian Wang, Wenling Wu, Liang Cai, Guangyan SN Compr Clin Med Covid-19 Coronavirus disease 2019 (COVID-19) not only causes pulmonary inflammation but also causes multiple organ damages, including the kidney. ACE2, as one of the receptors for SARS-CoV-2 intrusion, is widely distributed in kidney tissues. Currently, the diagnosis and treatment of SARS-CoV-2 infection in patients with chronic kidney disease (CKD) are still unclear. Here, we review the recent findings of characteristics of COVID-19 in CKD patients and highlight the possible mechanisms of kidney injury caused by SARS-CoV-2 infection. We then discuss the emerging therapeutic approaches aimed at reducing kidney damage and protecting kidney function including virus removal, immunotherapy, supporting treatment, special blood purification therapy, etc. Problems unresolved and challenges ahead are also discussed. Springer International Publishing 2020-09-23 2020 /pmc/articles/PMC7509500/ /pubmed/32984768 http://dx.doi.org/10.1007/s42399-020-00529-0 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Covid-19
Cheng, Yongqian
Wang, Wenling
Wu, Liang
Cai, Guangyan
SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title_full SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title_fullStr SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title_full_unstemmed SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title_short SARS-CoV-2-Related Kidney Injury: Current Concern and Challenges
title_sort sars-cov-2-related kidney injury: current concern and challenges
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509500/
https://www.ncbi.nlm.nih.gov/pubmed/32984768
http://dx.doi.org/10.1007/s42399-020-00529-0
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