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Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence

OBJECTIVE: Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but inactive N-terminal (NT) polypeptide (75SIRT1) and a C-terminal (CT) fragment. The present work examined if chondrocyte...

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Detalles Bibliográficos
Autores principales:	Batshon, George, Elayyan, Jinan, Qiq, Omar, Reich, Eli, Ben-Aderet, Louisa, Kandel, Leonid, Haze, Amir, Steinmeyer, Jürgen, Lefebvre, Veronique, Zhang, Hong, Elisseeff, Jennifer, Henrotin, Yves, Mobasheri, Ali, Dvir-Ginzberg, Mona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Osteoarthritis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509530/ https://www.ncbi.nlm.nih.gov/pubmed/32665267 http://dx.doi.org/10.1136/annrheumdis-2020-217072

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