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Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications
Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radia...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509662/ https://www.ncbi.nlm.nih.gov/pubmed/32999849 http://dx.doi.org/10.1002/advs.202001522 |
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author | Zeidell, Andrew M. Ren, Tong Filston, David S. Iqbal, Hamna F. Holland, Emma Bourland, J. Daniel Anthony, John E. Jurchescu, Oana D. |
author_facet | Zeidell, Andrew M. Ren, Tong Filston, David S. Iqbal, Hamna F. Holland, Emma Bourland, J. Daniel Anthony, John E. Jurchescu, Oana D. |
author_sort | Zeidell, Andrew M. |
collection | PubMed |
description | Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors faced by current technologies in approximating the dose profile in a patient's body, is sensitive for doses relevant to radiation treatment procedures, and robust when incorporated into conformal large‐area electronics. A model is proposed to describe the operation of RAD‐OFETs, based on the interplay between charge photogeneration and trapping. |
format | Online Article Text |
id | pubmed-7509662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75096622020-09-29 Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications Zeidell, Andrew M. Ren, Tong Filston, David S. Iqbal, Hamna F. Holland, Emma Bourland, J. Daniel Anthony, John E. Jurchescu, Oana D. Adv Sci (Weinh) Communications Radiation therapy is one of the most prevalent procedures for cancer treatment, but the risks of malignancies induced by peripheral beam in healthy tissues surrounding the target is high. Therefore, being able to accurately measure the exposure dose is a critical aspect of patient care. Here a radiation detector based on an organic field‐effect transistor (RAD‐OFET) is introduced, an in vivo dosimeter that can be placed directly on a patient's skin to validate in real time the dose being delivered and ensure that for nearby regions an acceptable level of low dose is being received. This device reduces the errors faced by current technologies in approximating the dose profile in a patient's body, is sensitive for doses relevant to radiation treatment procedures, and robust when incorporated into conformal large‐area electronics. A model is proposed to describe the operation of RAD‐OFETs, based on the interplay between charge photogeneration and trapping. John Wiley and Sons Inc. 2020-07-30 /pmc/articles/PMC7509662/ /pubmed/32999849 http://dx.doi.org/10.1002/advs.202001522 Text en © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Communications Zeidell, Andrew M. Ren, Tong Filston, David S. Iqbal, Hamna F. Holland, Emma Bourland, J. Daniel Anthony, John E. Jurchescu, Oana D. Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title | Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title_full | Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title_fullStr | Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title_full_unstemmed | Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title_short | Organic Field‐Effect Transistors as Flexible, Tissue‐Equivalent Radiation Dosimeters in Medical Applications |
title_sort | organic field‐effect transistors as flexible, tissue‐equivalent radiation dosimeters in medical applications |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509662/ https://www.ncbi.nlm.nih.gov/pubmed/32999849 http://dx.doi.org/10.1002/advs.202001522 |
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