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Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509663/ https://www.ncbi.nlm.nih.gov/pubmed/32999822 http://dx.doi.org/10.1002/advs.201901996 |
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author | Zhao, Ziqi Shang, Ziwei Vasconcelos, Zilton Li, Chunfeng Jiang, Yisheng Zu, Shulong Zhang, Jingyi Wang, Fengchao Yao, Li Jung, Jae U. Brasil, Patricia Moreira, Maria Elisabeth Qin, Cheng‐Feng Kerin, Tara Nielsen‐Saines, Karin Cheng, Genhong Zhang, Xiaohui Xu, Zhiheng |
author_facet | Zhao, Ziqi Shang, Ziwei Vasconcelos, Zilton Li, Chunfeng Jiang, Yisheng Zu, Shulong Zhang, Jingyi Wang, Fengchao Yao, Li Jung, Jae U. Brasil, Patricia Moreira, Maria Elisabeth Qin, Cheng‐Feng Kerin, Tara Nielsen‐Saines, Karin Cheng, Genhong Zhang, Xiaohui Xu, Zhiheng |
author_sort | Zhao, Ziqi |
collection | PubMed |
description | Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience‐dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood. |
format | Online Article Text |
id | pubmed-7509663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75096632020-09-29 Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children Zhao, Ziqi Shang, Ziwei Vasconcelos, Zilton Li, Chunfeng Jiang, Yisheng Zu, Shulong Zhang, Jingyi Wang, Fengchao Yao, Li Jung, Jae U. Brasil, Patricia Moreira, Maria Elisabeth Qin, Cheng‐Feng Kerin, Tara Nielsen‐Saines, Karin Cheng, Genhong Zhang, Xiaohui Xu, Zhiheng Adv Sci (Weinh) Full Papers Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience‐dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood. John Wiley and Sons Inc. 2020-08-02 /pmc/articles/PMC7509663/ /pubmed/32999822 http://dx.doi.org/10.1002/advs.201901996 Text en © 2020 The Authors. Published by Wiley‐VCH GmbH This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Zhao, Ziqi Shang, Ziwei Vasconcelos, Zilton Li, Chunfeng Jiang, Yisheng Zu, Shulong Zhang, Jingyi Wang, Fengchao Yao, Li Jung, Jae U. Brasil, Patricia Moreira, Maria Elisabeth Qin, Cheng‐Feng Kerin, Tara Nielsen‐Saines, Karin Cheng, Genhong Zhang, Xiaohui Xu, Zhiheng Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title_full | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title_fullStr | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title_full_unstemmed | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title_short | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children |
title_sort | zika virus infection leads to variable defects in multiple neurological functions and behaviors in mice and children |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509663/ https://www.ncbi.nlm.nih.gov/pubmed/32999822 http://dx.doi.org/10.1002/advs.201901996 |
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