TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

BACKGROUND: SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx and lung tissues as well as ne...

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Detalles Bibliográficos
Autores principales: Sacconi, Andrea, Donzelli, Sara, Pulito, Claudio, Ferrero, Stefano, Spinella, Francesca, Morrone, Aldo, Rigoni, Marta, Pimpinelli, Fulvia, Ensoli, Fabrizio, Sanguineti, Giuseppe, Pellini, Raul, Agrawal, Nishant, Izumchenko, Evgeny, Ciliberto, Gennaro, Giannì, Aldo, Muti, Paola, Strano, Sabrina, Blandino, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510014/
https://www.ncbi.nlm.nih.gov/pubmed/32967703
http://dx.doi.org/10.1186/s13046-020-01708-6

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