ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems

BACKGROUND: Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or adenine base editors can only accomplish C-to-T (G-to-A) or...

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Detalles Bibliográficos
Autores principales: Xie, Jingke, Huang, Xingyun, Wang, Xia, Gou, Shixue, Liang, Yanhui, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Zhang, Quanjun, Ge, Weikai, Jin, Qin, Shi, Hui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Wang, Jiaowei, Ye, Yinghua, Quan, Longquan, Wu, Han, Wang, Kepin, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510086/
https://www.ncbi.nlm.nih.gov/pubmed/32967664
http://dx.doi.org/10.1186/s12915-020-00866-5

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