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Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling
BACKGROUND: Different morphological structures of hairs having properties like defense and camouflage help animals survive in the wild environment. Horse is one of the rare kinds of animals with complex hair phenotypes in one individual; however, knowledge of horse hair follicle is limited in litera...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510135/ https://www.ncbi.nlm.nih.gov/pubmed/32962644 http://dx.doi.org/10.1186/s12864-020-07064-1 |
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author | Zhao, Ruoyang Yihan, Wu Zhao, Yiping Li, Bei Han, Haige Mongke, Togtokh Bao, Tugeqin Wang, Wenxing Dugarjaviin, Manglai Bai, Dongyi |
author_facet | Zhao, Ruoyang Yihan, Wu Zhao, Yiping Li, Bei Han, Haige Mongke, Togtokh Bao, Tugeqin Wang, Wenxing Dugarjaviin, Manglai Bai, Dongyi |
author_sort | Zhao, Ruoyang |
collection | PubMed |
description | BACKGROUND: Different morphological structures of hairs having properties like defense and camouflage help animals survive in the wild environment. Horse is one of the rare kinds of animals with complex hair phenotypes in one individual; however, knowledge of horse hair follicle is limited in literature and their molecular basis remains unclear. Therefore, the investigation of horse hair follicle morphogenesis and pigmentogenesis attracts considerable interest. RESULT: Histological studies revealed the morphology and pigment synthesis of hair follicles are different in between four different parts (mane, dorsal part, tail, and fetlock) of the bay Mongolian horse. Hair follicle size, density, and cycle are strongly associated with the activity of alkaline phosphatase (ALP). We observed a great difference in gene expression between the mane, tail, and fetlock, which had a greater different gene expression pattern compared with the dorsal part through transcriptomics. The development of the hair follicle in all four parts was related to angiogenesis, stem cells, Wnt, and IGF signaling pathways. Pigmentogenesis-related pathways were involved in their hair follicle pigment synthesis. CONCLUSIONS: Hair follicle morphology and the activity of ALP differ among four body parts in bay Mongolian horse. Hair follicles of the different body parts of the are not synchronized in their cycle stages. GO terms show a regional specificity pattern between different skin parts of the bay Mongolian horse. These results provide an insight into the understanding of the biological mechanism of the hair follicle in other mammals. |
format | Online Article Text |
id | pubmed-7510135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75101352020-09-24 Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling Zhao, Ruoyang Yihan, Wu Zhao, Yiping Li, Bei Han, Haige Mongke, Togtokh Bao, Tugeqin Wang, Wenxing Dugarjaviin, Manglai Bai, Dongyi BMC Genomics Research Article BACKGROUND: Different morphological structures of hairs having properties like defense and camouflage help animals survive in the wild environment. Horse is one of the rare kinds of animals with complex hair phenotypes in one individual; however, knowledge of horse hair follicle is limited in literature and their molecular basis remains unclear. Therefore, the investigation of horse hair follicle morphogenesis and pigmentogenesis attracts considerable interest. RESULT: Histological studies revealed the morphology and pigment synthesis of hair follicles are different in between four different parts (mane, dorsal part, tail, and fetlock) of the bay Mongolian horse. Hair follicle size, density, and cycle are strongly associated with the activity of alkaline phosphatase (ALP). We observed a great difference in gene expression between the mane, tail, and fetlock, which had a greater different gene expression pattern compared with the dorsal part through transcriptomics. The development of the hair follicle in all four parts was related to angiogenesis, stem cells, Wnt, and IGF signaling pathways. Pigmentogenesis-related pathways were involved in their hair follicle pigment synthesis. CONCLUSIONS: Hair follicle morphology and the activity of ALP differ among four body parts in bay Mongolian horse. Hair follicles of the different body parts of the are not synchronized in their cycle stages. GO terms show a regional specificity pattern between different skin parts of the bay Mongolian horse. These results provide an insight into the understanding of the biological mechanism of the hair follicle in other mammals. BioMed Central 2020-09-22 /pmc/articles/PMC7510135/ /pubmed/32962644 http://dx.doi.org/10.1186/s12864-020-07064-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Zhao, Ruoyang Yihan, Wu Zhao, Yiping Li, Bei Han, Haige Mongke, Togtokh Bao, Tugeqin Wang, Wenxing Dugarjaviin, Manglai Bai, Dongyi Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title | Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title_full | Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title_fullStr | Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title_full_unstemmed | Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title_short | Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling |
title_sort | hair follicle regional specificity in different parts of bay mongolian horse by histology and transcriptional profiling |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510135/ https://www.ncbi.nlm.nih.gov/pubmed/32962644 http://dx.doi.org/10.1186/s12864-020-07064-1 |
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