miR-146a-5p impairs melanoma resistance to kinase inhibitors by targeting COX2 and regulating NFkB-mediated inflammatory mediators

BACKGROUND: Targeted therapy with BRAF and MEK inhibitors has improved the survival of patients with BRAF-mutated metastatic melanoma, but most patients relapse upon the onset of drug resistance induced by mechanisms including genetic and epigenetic events. Among the epigenetic alterations, microRNA...

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Detalles Bibliográficos
Autores principales: Vergani, Elisabetta, Dugo, Matteo, Cossa, Mara, Frigerio, Simona, Di Guardo, Lorenza, Gallino, Gianfrancesco, Mattavelli, Ilaria, Vergani, Barbara, Lalli, Luca, Tamborini, Elena, Valeri, Barbara, Gargiuli, Chiara, Shahaj, Eriomina, Ferrarini, Marina, Ferrero, Elisabetta, Gomez Lira, Macarena, Huber, Veronica, Vecchio, Michele Del, Sensi, Marialuisa, Leone, Biagio Eugenio, Santinami, Mario, Rivoltini, Licia, Rodolfo, Monica, Vallacchi, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510138/
https://www.ncbi.nlm.nih.gov/pubmed/32967672
http://dx.doi.org/10.1186/s12964-020-00601-1

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