Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795

BACKGROUND: Adoptive transfer of engineered immune cells is a promising strategy for cancer treatment. However, low transduction efficiency particularly when large payload lentiviral vectors are used on primary T cells is a limitation for the development of cell therapy platforms that include multip...

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Detalles Bibliográficos
Autores principales: Li, Lingyu, Gao, Yuan, Srivastava, Richa, Wang, Wei, Xiong, Qinghui, Fang, Zhiming, Pelayo, Alejandra, Denson, Carolyn, Goswami, Angshumala, Harari-Steinfeld, Rona, Yang, Zhifen, Weng, Lihong, Qi, Lei Stanley, Marincola, Francesco M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510327/
https://www.ncbi.nlm.nih.gov/pubmed/32967676
http://dx.doi.org/10.1186/s12967-020-02526-2

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