SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching

BACKGROUND: Mesenchymal stem cells (MSCs) have therapeutic potential for multiple ischemic diseases. However, in vitro expansion of MSCs before clinical application leads to metabolic reprogramming from glycolysis to oxidative phosphorylation, drastically impairing their proliferative and therapeuti...

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Detalles Bibliográficos
Autores principales: Ou, Tiantong, Yang, Wenlong, Li, Wenjia, Lu, Yijing, Dong, Zheng, Zhu, Hongming, Sun, Xiaolei, Dong, Zhen, Weng, Xinyu, Chang, Suchi, Li, Hua, Li, Yufan, Qiu, Zhiwei, Hu, Kai, Sun, Aijun, Ge, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510333/
https://www.ncbi.nlm.nih.gov/pubmed/32997407
http://dx.doi.org/10.1002/ctm2.172

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