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S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery

Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficien...

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Autores principales: Wang, Changping, Liu, Chongyi, Wei, Qiyao, Yang, Lei, Yang, Peng, Li, Yiwen, Cheng, Yiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510344/
https://www.ncbi.nlm.nih.gov/pubmed/33015634
http://dx.doi.org/10.34133/2020/6563091
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author Wang, Changping
Liu, Chongyi
Wei, Qiyao
Yang, Lei
Yang, Peng
Li, Yiwen
Cheng, Yiyun
author_facet Wang, Changping
Liu, Chongyi
Wei, Qiyao
Yang, Lei
Yang, Peng
Li, Yiwen
Cheng, Yiyun
author_sort Wang, Changping
collection PubMed
description Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties.
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spelling pubmed-75103442020-10-01 S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery Wang, Changping Liu, Chongyi Wei, Qiyao Yang, Lei Yang, Peng Li, Yiwen Cheng, Yiyun Research (Wash D C) Research Article Photocleavable hydrogels are of great importance in the field of controlled drug delivery, stem cell fate regulation, surface patterning, and intelligent devices. However, the development of novel photocleavable gel systems by visible light is usually met with challenges such as the lack of efficient and tunable photocleavable groups and reactions. Herein, we reported the facile fabrication of a new type of photocleavable hydrogels by the direct gelation of 4-arm thiol-terminated polyethylene glycol with 3,6-dichloro-1,2,4,5-tetrazine via the formation of S,S-tetrazine linkages. The prepared hydrogels underwent efficient degradation upon irradiation by ultraviolet or green light, and the degradation kinetics could be significantly promoted by hydrogen peroxide. Correspondingly, the hydrogels loaded with calcium peroxide microparticles or glucose oxidase/catalase enzymes enabled the precise and efficient in vivo photocontrol of gel degradation and drug release for cancer treatment. This work offers a promising and facile strategy towards the fabrication of visible light cleavable hydrogels with tunable and on-demand drug release properties. AAAS 2020-09-04 /pmc/articles/PMC7510344/ /pubmed/33015634 http://dx.doi.org/10.34133/2020/6563091 Text en Copyright © 2020 Changping Wang et al. https://creativecommons.org/licenses/by/4.0/ Exclusive Licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0).
spellingShingle Research Article
Wang, Changping
Liu, Chongyi
Wei, Qiyao
Yang, Lei
Yang, Peng
Li, Yiwen
Cheng, Yiyun
S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title_full S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title_fullStr S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title_full_unstemmed S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title_short S,S-Tetrazine-Based Hydrogels with Visible Light Cleavable Properties for On-Demand Anticancer Drug Delivery
title_sort s,s-tetrazine-based hydrogels with visible light cleavable properties for on-demand anticancer drug delivery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510344/
https://www.ncbi.nlm.nih.gov/pubmed/33015634
http://dx.doi.org/10.34133/2020/6563091
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