Role of platelet-derived growth factor in type II diabetes mellitus and its complications

Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic nephropathy, diabetic retinopathy, and diabetic foot. Platelet-derived growth factors are growth factors that regulate cell growth and...

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Detalles Bibliográficos
Autores principales: Shen, Sihong, Wang, Fuyan, Fernandez, Alejandra, Hu, Weining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510352/
https://www.ncbi.nlm.nih.gov/pubmed/32744067
http://dx.doi.org/10.1177/1479164120942119
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author Shen, Sihong
Wang, Fuyan
Fernandez, Alejandra
Hu, Weining
author_facet Shen, Sihong
Wang, Fuyan
Fernandez, Alejandra
Hu, Weining
author_sort Shen, Sihong
collection PubMed
description Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic nephropathy, diabetic retinopathy, and diabetic foot. Platelet-derived growth factors are growth factors that regulate cell growth and division, playing a critical role in diabetes and its harmful complications. This review focused on the cellular mechanism of platelet-derived growth factors and their receptors on diabetes development. Furthermore, we raise some proper therapeutic molecular targets for the treatment of diabetes and its complications.
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spelling pubmed-75103522021-03-02 Role of platelet-derived growth factor in type II diabetes mellitus and its complications Shen, Sihong Wang, Fuyan Fernandez, Alejandra Hu, Weining Diab Vasc Dis Res Review Article Type 2 diabetes mellitus is a type of metabolic disorder characterized by hyperglycaemia with multiple serious complications, such as diabetic neuropathies, diabetic nephropathy, diabetic retinopathy, and diabetic foot. Platelet-derived growth factors are growth factors that regulate cell growth and division, playing a critical role in diabetes and its harmful complications. This review focused on the cellular mechanism of platelet-derived growth factors and their receptors on diabetes development. Furthermore, we raise some proper therapeutic molecular targets for the treatment of diabetes and its complications. SAGE Publications 2020-08-02 /pmc/articles/PMC7510352/ /pubmed/32744067 http://dx.doi.org/10.1177/1479164120942119 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Shen, Sihong
Wang, Fuyan
Fernandez, Alejandra
Hu, Weining
Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title_full Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title_fullStr Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title_full_unstemmed Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title_short Role of platelet-derived growth factor in type II diabetes mellitus and its complications
title_sort role of platelet-derived growth factor in type ii diabetes mellitus and its complications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510352/
https://www.ncbi.nlm.nih.gov/pubmed/32744067
http://dx.doi.org/10.1177/1479164120942119
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AT huweining roleofplateletderivedgrowthfactorintypeiidiabetesmellitusanditscomplications

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