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A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

The SARS-CoV-2 pandemic has caused extreme human suffering and economic harm. We generated and characterized a new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice. This SARS-CoV-2 model exhibits the spectrum of morbidity and mortal...

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Detalles Bibliográficos
Autores principales:	Leist, Sarah R., Dinnon, Kenneth H., Schäfer, Alexandra, Tse, Longping V., Okuda, Kenichi, Hou, Yixuan J., West, Ande, Edwards, Caitlin E., Sanders, Wes, Fritch, Ethan J., Gully, Kendra L., Scobey, Trevor, Brown, Ariane J., Sheahan, Timothy P., Moorman, Nathaniel J., Boucher, Richard C., Gralinski, Lisa E., Montgomery, Stephanie A., Baric, Ralph S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2020
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510428/ https://www.ncbi.nlm.nih.gov/pubmed/33031744 http://dx.doi.org/10.1016/j.cell.2020.09.050

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