The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

N6-methyladenosine (m(6)A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M(6)A can be catalyzed by m(6)A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m(6)A -bindi...

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Detalles Bibliográficos
Autores principales: Li, Yang, Ge, Yu-zheng, Xu, Luwei, Xu, Zheng, Dou, Quanliang, Jia, Ruipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510505/
https://www.ncbi.nlm.nih.gov/pubmed/33015074
http://dx.doi.org/10.3389/fcell.2020.579919
Descripción
Sumario:N6-methyladenosine (m(6)A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M(6)A can be catalyzed by m(6)A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m(6)A -binding proteins such as YTHDF1/2/3, IGF2BP1/2/3 and HNRNPA2B1 (readers). Emerging evidence suggests that m(6)A modification is significant for regulating many biological and cellular processes and participates in the pathological development of various diseases, including tumors. This article reviews recent studies on the biological function of m(6)A modification and the methylation modification of m(6)A in urological tumors.

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