The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

N6-methyladenosine (m(6)A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M(6)A can be catalyzed by m(6)A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m(6)A -bindi...

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Autores principales: Li, Yang, Ge, Yu-zheng, Xu, Luwei, Xu, Zheng, Dou, Quanliang, Jia, Ruipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510505/
https://www.ncbi.nlm.nih.gov/pubmed/33015074
http://dx.doi.org/10.3389/fcell.2020.579919
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author Li, Yang
Ge, Yu-zheng
Xu, Luwei
Xu, Zheng
Dou, Quanliang
Jia, Ruipeng
author_facet Li, Yang
Ge, Yu-zheng
Xu, Luwei
Xu, Zheng
Dou, Quanliang
Jia, Ruipeng
author_sort Li, Yang
collection PubMed
description N6-methyladenosine (m(6)A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M(6)A can be catalyzed by m(6)A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m(6)A -binding proteins such as YTHDF1/2/3, IGF2BP1/2/3 and HNRNPA2B1 (readers). Emerging evidence suggests that m(6)A modification is significant for regulating many biological and cellular processes and participates in the pathological development of various diseases, including tumors. This article reviews recent studies on the biological function of m(6)A modification and the methylation modification of m(6)A in urological tumors.
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spelling pubmed-75105052020-10-02 The Potential Roles of RNA N6-Methyladenosine in Urological Tumors Li, Yang Ge, Yu-zheng Xu, Luwei Xu, Zheng Dou, Quanliang Jia, Ruipeng Front Cell Dev Biol Cell and Developmental Biology N6-methyladenosine (m(6)A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M(6)A can be catalyzed by m(6)A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m(6)A -binding proteins such as YTHDF1/2/3, IGF2BP1/2/3 and HNRNPA2B1 (readers). Emerging evidence suggests that m(6)A modification is significant for regulating many biological and cellular processes and participates in the pathological development of various diseases, including tumors. This article reviews recent studies on the biological function of m(6)A modification and the methylation modification of m(6)A in urological tumors. Frontiers Media S.A. 2020-09-09 /pmc/articles/PMC7510505/ /pubmed/33015074 http://dx.doi.org/10.3389/fcell.2020.579919 Text en Copyright © 2020 Li, Ge, Xu, Xu, Dou and Jia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Yang
Ge, Yu-zheng
Xu, Luwei
Xu, Zheng
Dou, Quanliang
Jia, Ruipeng
The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_full The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_fullStr The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_full_unstemmed The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_short The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_sort potential roles of rna n6-methyladenosine in urological tumors
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510505/
https://www.ncbi.nlm.nih.gov/pubmed/33015074
http://dx.doi.org/10.3389/fcell.2020.579919
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