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Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects

Development of specific antiviral agents is an urgent unmet need for SARS-coronavirus 2 (SARS-CoV-2) infection. This study focuses on host proteases that proteolytically activate the SARS-CoV-2 spike protein, critical for its fusion after binding to angiotensin-converting enzyme 2 (ACE2), as antivir...

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Detalles Bibliográficos
Autores principales:	Cheng, Ya-Wen, Chao, Tai-Ling, Li, Chiao-Ling, Chiu, Mu-Fan, Kao, Han-Chieh, Wang, Sheng-Han, Pang, Yu-Hao, Lin, Chih-Hui, Tsai, Ya-Min, Lee, Wen-Hau, Tao, Mi-Hua, Ho, Tung-Ching, Wu, Ping-Yi, Jang, Li-Ting, Chen, Pei-Jer, Chang, Sui-Yuan, Yeh, Shiou-Hwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510585/ https://www.ncbi.nlm.nih.gov/pubmed/33007239 http://dx.doi.org/10.1016/j.celrep.2020.108254

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