Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results

Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that u...

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Autores principales: Das, Marie K., Chaudhary, Anu, Bryan, Andrew, Wener, Mark H., Fink, Susan L., Morishima, Chihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510736/
https://www.ncbi.nlm.nih.gov/pubmed/32723430
http://dx.doi.org/10.3201/eid2610.202632
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author Das, Marie K.
Chaudhary, Anu
Bryan, Andrew
Wener, Mark H.
Fink, Susan L.
Morishima, Chihiro
author_facet Das, Marie K.
Chaudhary, Anu
Bryan, Andrew
Wener, Mark H.
Fink, Susan L.
Morishima, Chihiro
author_sort Das, Marie K.
collection PubMed
description Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance.
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spelling pubmed-75107362020-10-02 Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results Das, Marie K. Chaudhary, Anu Bryan, Andrew Wener, Mark H. Fink, Susan L. Morishima, Chihiro Emerg Infect Dis Research Letter Many serologic tests are now available for measuring severe acute respiratory syndrome coronavirus 2 antibodies to evaluate potential protective immunity and for seroprevalence studies. We describe an approach to standardizing positivity thresholds and quantitative values for different assays that uses z-scores to enable rapid and efficient comparison of serologic test performance. Centers for Disease Control and Prevention 2020-10 /pmc/articles/PMC7510736/ /pubmed/32723430 http://dx.doi.org/10.3201/eid2610.202632 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Das, Marie K.
Chaudhary, Anu
Bryan, Andrew
Wener, Mark H.
Fink, Susan L.
Morishima, Chihiro
Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title_full Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title_fullStr Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title_full_unstemmed Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title_short Rapid Screening Evaluation of SARS-CoV-2 IgG Assays Using Z-Scores to Standardize Results
title_sort rapid screening evaluation of sars-cov-2 igg assays using z-scores to standardize results
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510736/
https://www.ncbi.nlm.nih.gov/pubmed/32723430
http://dx.doi.org/10.3201/eid2610.202632
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