Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin

US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE a...

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Detalles Bibliográficos
Autores principales: Bett, Cyrus, Andrews, Omozusi, Asher, David M., Pilant, Teresa, Keire, David, Gregori, Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510749/
https://www.ncbi.nlm.nih.gov/pubmed/32723431
http://dx.doi.org/10.3201/eid2610.200142
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author Bett, Cyrus
Andrews, Omozusi
Asher, David M.
Pilant, Teresa
Keire, David
Gregori, Luisa
author_facet Bett, Cyrus
Andrews, Omozusi
Asher, David M.
Pilant, Teresa
Keire, David
Gregori, Luisa
author_sort Bett, Cyrus
collection PubMed
description US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrP(TSE)).
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spelling pubmed-75107492020-10-02 Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin Bett, Cyrus Andrews, Omozusi Asher, David M. Pilant, Teresa Keire, David Gregori, Luisa Emerg Infect Dis Research Letter US manufacturers, concerned about bovine spongiform encephalopathy (BSE), ceased marketing bovine heparin in the 1990s. Recent short supplies of safe porcine heparin suggest that reintroducing bovine heparin might benefit public health. We purified heparin from crude bovine extract spiked with BSE agent, removing substantial infectivity and abnormal prion proteins (PrP(TSE)). Centers for Disease Control and Prevention 2020-10 /pmc/articles/PMC7510749/ /pubmed/32723431 http://dx.doi.org/10.3201/eid2610.200142 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Bett, Cyrus
Andrews, Omozusi
Asher, David M.
Pilant, Teresa
Keire, David
Gregori, Luisa
Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title_full Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title_fullStr Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title_full_unstemmed Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title_short Eliminating Spiked Bovine Spongiform Encephalopathy Agent Activity from Heparin
title_sort eliminating spiked bovine spongiform encephalopathy agent activity from heparin
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510749/
https://www.ncbi.nlm.nih.gov/pubmed/32723431
http://dx.doi.org/10.3201/eid2610.200142
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