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Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield
Metabolic addiction, an organism that is metabolically addicted with a compound to maintain its growth fitness, is an underexplored area in metabolic engineering. Microbes with heavily engineered pathways or genetic circuits tend to experience metabolic burden leading to degenerated or abortive prod...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510839/ https://www.ncbi.nlm.nih.gov/pubmed/32445959 http://dx.doi.org/10.1016/j.ymben.2020.05.005 |