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Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, wit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510926/ https://www.ncbi.nlm.nih.gov/pubmed/33014545 http://dx.doi.org/10.1364/BOE.393586 |
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author | Papadimitriou, Konstantinos I. Vidal Rosas, Ernesto E. Zhang, Edward Cooper, Robert J. Hebden, Jeremy C. Arridge, Simon R. Powell, Samuel |
author_facet | Papadimitriou, Konstantinos I. Vidal Rosas, Ernesto E. Zhang, Edward Cooper, Robert J. Hebden, Jeremy C. Arridge, Simon R. Powell, Samuel |
author_sort | Papadimitriou, Konstantinos I. |
collection | PubMed |
description | Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments. |
format | Online Article Text |
id | pubmed-7510926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-75109262020-10-01 Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses Papadimitriou, Konstantinos I. Vidal Rosas, Ernesto E. Zhang, Edward Cooper, Robert J. Hebden, Jeremy C. Arridge, Simon R. Powell, Samuel Biomed Opt Express Article Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments. Optical Society of America 2020-06-02 /pmc/articles/PMC7510926/ /pubmed/33014545 http://dx.doi.org/10.1364/BOE.393586 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. |
spellingShingle | Article Papadimitriou, Konstantinos I. Vidal Rosas, Ernesto E. Zhang, Edward Cooper, Robert J. Hebden, Jeremy C. Arridge, Simon R. Powell, Samuel Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title | Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title_full | Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title_fullStr | Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title_full_unstemmed | Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title_short | Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
title_sort | dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510926/ https://www.ncbi.nlm.nih.gov/pubmed/33014545 http://dx.doi.org/10.1364/BOE.393586 |
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