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Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses

Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, wit...

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Detalles Bibliográficos
Autores principales: Papadimitriou, Konstantinos I., Vidal Rosas, Ernesto E., Zhang, Edward, Cooper, Robert J., Hebden, Jeremy C., Arridge, Simon R., Powell, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510926/
https://www.ncbi.nlm.nih.gov/pubmed/33014545
http://dx.doi.org/10.1364/BOE.393586
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author Papadimitriou, Konstantinos I.
Vidal Rosas, Ernesto E.
Zhang, Edward
Cooper, Robert J.
Hebden, Jeremy C.
Arridge, Simon R.
Powell, Samuel
author_facet Papadimitriou, Konstantinos I.
Vidal Rosas, Ernesto E.
Zhang, Edward
Cooper, Robert J.
Hebden, Jeremy C.
Arridge, Simon R.
Powell, Samuel
author_sort Papadimitriou, Konstantinos I.
collection PubMed
description Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments.
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spelling pubmed-75109262020-10-01 Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses Papadimitriou, Konstantinos I. Vidal Rosas, Ernesto E. Zhang, Edward Cooper, Robert J. Hebden, Jeremy C. Arridge, Simon R. Powell, Samuel Biomed Opt Express Article Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments. Optical Society of America 2020-06-02 /pmc/articles/PMC7510926/ /pubmed/33014545 http://dx.doi.org/10.1364/BOE.393586 Text en Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) . Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
spellingShingle Article
Papadimitriou, Konstantinos I.
Vidal Rosas, Ernesto E.
Zhang, Edward
Cooper, Robert J.
Hebden, Jeremy C.
Arridge, Simon R.
Powell, Samuel
Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title_full Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title_fullStr Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title_full_unstemmed Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title_short Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
title_sort dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510926/
https://www.ncbi.nlm.nih.gov/pubmed/33014545
http://dx.doi.org/10.1364/BOE.393586
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