Cargando…

Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

Aflatoxin B1 (AFB1), a mycotoxin, is acutely hepatotoxic to many animals including humans. However, there are marked interspecies differences in sensitivity to AFB1-induced toxicity depending on bioactivation by cytochrome P450s (CYPs). In the present study, we examined the applicability of chimeric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishida, Yuji, Yamasaki, Chihiro, Iwanari, Hiroko, Yamashita, Hisahiko, Ogawa, Yuko, Yanagi, Ami, Furukawa, Suzue, Kojima, Yuha, Chayama, Kazuaki, Kamiie, Junichi, Tateno, Chise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510964/ https://www.ncbi.nlm.nih.gov/pubmed/32966316 http://dx.doi.org/10.1371/journal.pone.0239540

Ejemplares similares

Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs
por: Yamasaki, Chihiro, et al.
Publicado: (2020)

Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency
por: Sugahara, Go, et al.
Publicado: (2020)

Characterization and applications of chimeric mice with humanized livers for preclinical drug development
por: Tateno, Chise, et al.
Publicado: (2020)

Estimating Drug Efficacy with a Diet-Induced NASH Model in Chimeric Mice with Humanized Livers
por: Kisoh, Keishi, et al.
Publicado: (2021)

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies
por: Kakuni, Masakazu, et al.
Publicado: (2013)

A Human Hepatocyte-Bearing Mouse: An Animal Model to Predict Drug Metabolism and Effectiveness in Humans
por: Yoshizato, Katsutoshi, et al.
Publicado: (2009)

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice
por: Tateno, Chise, et al.
Publicado: (2015)

Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4α (HNF4α) isoforms in human and rats
por: Jiang, Shuying, et al.
Publicado: (2003)

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
por: de la Rosa Rodriguez, Montserrat A., et al.
Publicado: (2018)

Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse
por: Tsuge, Masataka, et al.
Publicado: (2011)

Prediction of human pharmacokinetics for low‐clearance compounds using pharmacokinetic data from chimeric mice with humanized livers
por: Yoshida, Kosuke, et al.
Publicado: (2021)

Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection
por: Nakagawa, Shin-ichiro, et al.
Publicado: (2013)

Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP
por: Makokha, Grace Naswa, et al.
Publicado: (2019)

Publisher Correction: Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP
por: Makokha, Grace Naswa, et al.
Publicado: (2020)

Functional changes of cocultured hepatocyte sheets subjected to continuous liver regeneration stimulation in cDNA-uPA/SCID mouse: Differences in transplantation sites
por: Miyamoto, Daisuke, et al.
Publicado: (2021)

Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles
por: Sanada, Takahiro, et al.
Publicado: (2016)

Establishment of a monoclonal antibody for human LXRα: Detection of LXRα protein expression in human macrophages
por: Watanabe, Yuichiro, et al.
Publicado: (2003)

Early Multiphasic HBV Infection Initiation Kinetics Is Not Clone-Specific and Is Not Affected by Hepatitis D Virus (HDV) Infection
por: Tsuge, Masataka, et al.
Publicado: (2019)

Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice
por: Zou, Chenhui, et al.
Publicado: (2020)

Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes
por: Akahori, Yuichi, et al.
Publicado: (2020)

Interferon alpha treatment stimulates interferon gamma expression in type I NKT cells and enhances their antiviral effect against hepatitis C virus
por: Miyaki, Eisuke, et al.
Publicado: (2017)

The effect of aflatoxins on the incorporation of RNA and protein precursors by isolated hepatocytes.
por: McIntosh, P. R., et al.
Publicado: (1976)

Comparative metabolism of aflatoxin B(1) in mouse, rat and human primary hepatocytes using HPLC–MS/MS
por: Gerdemann, Andrea, et al.
Publicado: (2023)

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice
por: Foquet, Lander, et al.
Publicado: (2013)

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen
por: Baudi, Ian, et al.
Publicado: (2021)

Persistent hepatic IFN system activation in HBV-HDV infection determines viral replication dynamics and therapeutic response
por: Chida, Takeshi, et al.
Publicado: (2023)

Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics
por: Hailegiorgis, Atesmachew, et al.
Publicado: (2023)

Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells
por: Yang, Jiayin, et al.
Publicado: (2017)

Aflatoxin B(1) invokes apoptosis via death receptor pathway in hepatocytes
por: Mughal, Muhammad Jameel, et al.
Publicado: (2016)

The Individual and Combined Effects of Deoxynivalenol and Aflatoxin B(1) on Primary Hepatocytes of Cyprinus Carpio
por: He, Cheng-Hua, et al.
Publicado: (2010)

Analysis of miRNA‐mRNA regulatory network revealed key genes induced by aflatoxin B1 exposure in primary human hepatocytes
por: Zhang, Ziyang, et al.
Publicado: (2019)

Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene
por: Watanabe, Tsunamasa, et al.
Publicado: (2013)

Microphysical space of a liver sinusoid device enables simplified long-term maintenance of chimeric mouse-expanded human hepatocytes
por: Maher, Steven P., et al.
Publicado: (2014)

Human hepatocyte carcinogenesis
por: SHIRAHA, HIDENORI, et al.
Publicado: (2013)

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion
por: Ma, Christopher D., et al.
Publicado: (2020)

The Efficacy of the Hepatocyte Spheroids for Hepatocyte Transplantation
por: Shibuya, Kazuaki, et al.
Publicado: (2021)

A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection
por: Yuan, Lunzhi, et al.
Publicado: (2018)

Low-dose ethanol increases aflatoxin production due to the adh1-dependent incorporation of ethanol into aflatoxin biosynthesis
por: Furukawa, Tomohiro, et al.
Publicado: (2023)

Smoking Cessation Reverses DNA Double-Strand Breaks in Human Mononuclear Cells
por: Ishida, Mari, et al.
Publicado: (2014)

Establishment and Characterization of Mouse‐Human Chimeric Monoclonal Antibody to erbB‐2 Product
por: Ishida, Tadao, et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_4gaagaoov2bgrr4kkmbndhkf1v