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Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 (sCL-12) synergizes complement alternative pathway (AP) activation. However, wheth...

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Detalles Bibliográficos
Autores principales:	Zhang, Jie, Song, Lihong, Pedersen, Dennis V, Li, Anna, Lambris, John D, Andersen, Gregers Rom, Mollnes, Tom Eirik, Ma, Ying Jie, Garred, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511233/ https://www.ncbi.nlm.nih.gov/pubmed/32909942 http://dx.doi.org/10.7554/eLife.60908

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