Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity

Kinase inhibitors (KIs) represent an important class of anti-cancer drugs. Although cardiotoxicity is a serious adverse event associated with several KIs, the reasons remain poorly understood, and its prediction remains challenging. We obtain transcriptional profiles of human heart-derived primary c...

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Detalles Bibliográficos
Autores principales: van Hasselt, J. G. Coen, Rahman, Rayees, Hansen, Jens, Stern, Alan, Shim, Jaehee V., Xiong, Yuguang, Pickard, Amanda, Jayaraman, Gomathi, Hu, Bin, Mahajan, Milind, Gallo, James M., Goldfarb, Joseph, Sobie, Eric A., Birtwistle, Marc R., Schlessinger, Avner, Azeloglu, Evren U., Iyengar, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511315/
https://www.ncbi.nlm.nih.gov/pubmed/32968055
http://dx.doi.org/10.1038/s41467-020-18396-7

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