Polyol and sugar osmolytes can shorten protein hydrogen bonds to modulate function

Polyol and sugar osmolytes are commonly used in therapeutic protein formulations. How they may affect protein structure and function is an important question. In this work, through NMR measurements, we show that glycerol and sorbitol (polyols), as well as glucose (sugar), can shorten protein backbon...

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Detalles Bibliográficos
Autores principales: Li, Jingwen, Chen, Jingfei, An, Liaoyuan, Yuan, Xiaoxiang, Yao, Lishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511342/
https://www.ncbi.nlm.nih.gov/pubmed/32968183
http://dx.doi.org/10.1038/s42003-020-01260-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511342/
https://www.ncbi.nlm.nih.gov/pubmed/32968183
http://dx.doi.org/10.1038/s42003-020-01260-1

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