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Stability and robustness of asymptotic autocatalytic systems

Here, we address the consequences of the extension in the space of a simple model of a system that is closed to efficient causation: the (M,R)-system model. To do so, we use a diffusion term to describe the collective motion of the nutrients’ concentration across the compartmentalized space that def...

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Autores principales: Yun-Cárcamo, Sohyoun, Carrasco, Sebastián, Rogan, José, Correa-Burrows, Paulina, Valdivia, Juan Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511346/
https://www.ncbi.nlm.nih.gov/pubmed/32968157
http://dx.doi.org/10.1038/s41598-020-72580-9
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author Yun-Cárcamo, Sohyoun
Carrasco, Sebastián
Rogan, José
Correa-Burrows, Paulina
Valdivia, Juan Alejandro
author_facet Yun-Cárcamo, Sohyoun
Carrasco, Sebastián
Rogan, José
Correa-Burrows, Paulina
Valdivia, Juan Alejandro
author_sort Yun-Cárcamo, Sohyoun
collection PubMed
description Here, we address the consequences of the extension in the space of a simple model of a system that is closed to efficient causation: the (M,R)-system model. To do so, we use a diffusion term to describe the collective motion of the nutrients’ concentration across the compartmentalized space that defines the organism. We show that the non-trivial stable steady state remains despite such generalization, as long as the system is small enough to deal with the transport of the precursors to feed the entire protocell and dispose of a sufficient concentration of it in its surroundings. Such consideration explains the emergence of a bifurcation with two parameters that we characterize. Finally, we show that the robustness of the system under catastrophic losses of catalysts also remains, preserving the original’s model character.
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spelling pubmed-75113462020-09-24 Stability and robustness of asymptotic autocatalytic systems Yun-Cárcamo, Sohyoun Carrasco, Sebastián Rogan, José Correa-Burrows, Paulina Valdivia, Juan Alejandro Sci Rep Article Here, we address the consequences of the extension in the space of a simple model of a system that is closed to efficient causation: the (M,R)-system model. To do so, we use a diffusion term to describe the collective motion of the nutrients’ concentration across the compartmentalized space that defines the organism. We show that the non-trivial stable steady state remains despite such generalization, as long as the system is small enough to deal with the transport of the precursors to feed the entire protocell and dispose of a sufficient concentration of it in its surroundings. Such consideration explains the emergence of a bifurcation with two parameters that we characterize. Finally, we show that the robustness of the system under catastrophic losses of catalysts also remains, preserving the original’s model character. Nature Publishing Group UK 2020-09-23 /pmc/articles/PMC7511346/ /pubmed/32968157 http://dx.doi.org/10.1038/s41598-020-72580-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yun-Cárcamo, Sohyoun
Carrasco, Sebastián
Rogan, José
Correa-Burrows, Paulina
Valdivia, Juan Alejandro
Stability and robustness of asymptotic autocatalytic systems
title Stability and robustness of asymptotic autocatalytic systems
title_full Stability and robustness of asymptotic autocatalytic systems
title_fullStr Stability and robustness of asymptotic autocatalytic systems
title_full_unstemmed Stability and robustness of asymptotic autocatalytic systems
title_short Stability and robustness of asymptotic autocatalytic systems
title_sort stability and robustness of asymptotic autocatalytic systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511346/
https://www.ncbi.nlm.nih.gov/pubmed/32968157
http://dx.doi.org/10.1038/s41598-020-72580-9
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