Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development

Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections...

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Detalles Bibliográficos
Autores principales: Ambati, Jayakrishna, Magagnoli, Joseph, Leung, Hannah, Wang, Shao-bin, Andrews, Chris A., Fu, Dongxu, Pandey, Akshat, Sahu, Srabani, Narendran, Siddharth, Hirahara, Shuichiro, Fukuda, Shinichi, Sun, Jian, Pandya, Lekha, Ambati, Meenakshi, Pereira, Felipe, Varshney, Akhil, Cummings, Tammy, Hardin, James W., Edun, Babatunde, Bennett, Charles L., Ambati, Kameshwari, Fowler, Benjamin J., Kerur, Nagaraj, Röver, Christian, Leitinger, Norbert, Werner, Brian C., Stein, Joshua D., Sutton, S. Scott, Gelfand, Bradley D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511405/
https://www.ncbi.nlm.nih.gov/pubmed/32968070
http://dx.doi.org/10.1038/s41467-020-18528-z

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