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Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa

People with anorexia nervosa (AN) commonly exhibit social difficulties, which may be related to problems with understanding the perspectives of others, commonly known as Theory of Mind (ToM) processing. However, there is a dearth of literature investigating the neural basis of these differences in T...

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Autores principales: Leslie, Monica, Halls, Daniel, Leppanen, Jenni, Sedgewick, Felicity, Smith, Katherine, Hayward, Hannah, Lang, Katie, Fonville, Leon, Simic, Mima, Mandy, William, Nicholls, Dasha, Murphy, Declan, Williams, Steven, Tchanturia, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511528/
https://www.ncbi.nlm.nih.gov/pubmed/33013605
http://dx.doi.org/10.3389/fpsyg.2020.568073
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author Leslie, Monica
Halls, Daniel
Leppanen, Jenni
Sedgewick, Felicity
Smith, Katherine
Hayward, Hannah
Lang, Katie
Fonville, Leon
Simic, Mima
Mandy, William
Nicholls, Dasha
Murphy, Declan
Williams, Steven
Tchanturia, Kate
author_facet Leslie, Monica
Halls, Daniel
Leppanen, Jenni
Sedgewick, Felicity
Smith, Katherine
Hayward, Hannah
Lang, Katie
Fonville, Leon
Simic, Mima
Mandy, William
Nicholls, Dasha
Murphy, Declan
Williams, Steven
Tchanturia, Kate
author_sort Leslie, Monica
collection PubMed
description People with anorexia nervosa (AN) commonly exhibit social difficulties, which may be related to problems with understanding the perspectives of others, commonly known as Theory of Mind (ToM) processing. However, there is a dearth of literature investigating the neural basis of these differences in ToM and at what age they emerge. This study aimed to test for differences in the neural correlates of ToM processes in young women with AN, and young women weight-restored (WR) from AN, as compared to healthy control participants (HC). Based on previous findings in AN, we hypothesized that young women with current or prior AN, as compared to HCs, would exhibit a reduced neural response in the medial prefrontal cortex (mPFC), the inferior frontal gyrus, and the temporo-parietal junction (TPJ) whilst completing a ToM task. We recruited 73 young women with AN, 45 WR young women, and 70 young women without a history of AN to take part in the current study. Whilst undergoing a functional magnetic resonance imaging (fMRI) scan, participants completed the Frith-Happé task, which is a commonly used measure of ToM with demonstrated reliability and validity in adult populations. In this task, participants viewed the movements of triangles, which depicted either action movements, simple interactions, or complex social interactions. Viewing trials with more complex social interactions in the Frith-Happé task was associated with increased brain activation in regions including the right TPJ, the bilateral mPFC, the cerebellum, and the dorsolateral prefrontal cortex. There were no group differences in neural activation in response to the ToM contrast. Overall, these results suggest that the neural basis of spontaneous mentalizing is preserved in most young women with AN.
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spelling pubmed-75115282020-10-02 Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa Leslie, Monica Halls, Daniel Leppanen, Jenni Sedgewick, Felicity Smith, Katherine Hayward, Hannah Lang, Katie Fonville, Leon Simic, Mima Mandy, William Nicholls, Dasha Murphy, Declan Williams, Steven Tchanturia, Kate Front Psychol Psychology People with anorexia nervosa (AN) commonly exhibit social difficulties, which may be related to problems with understanding the perspectives of others, commonly known as Theory of Mind (ToM) processing. However, there is a dearth of literature investigating the neural basis of these differences in ToM and at what age they emerge. This study aimed to test for differences in the neural correlates of ToM processes in young women with AN, and young women weight-restored (WR) from AN, as compared to healthy control participants (HC). Based on previous findings in AN, we hypothesized that young women with current or prior AN, as compared to HCs, would exhibit a reduced neural response in the medial prefrontal cortex (mPFC), the inferior frontal gyrus, and the temporo-parietal junction (TPJ) whilst completing a ToM task. We recruited 73 young women with AN, 45 WR young women, and 70 young women without a history of AN to take part in the current study. Whilst undergoing a functional magnetic resonance imaging (fMRI) scan, participants completed the Frith-Happé task, which is a commonly used measure of ToM with demonstrated reliability and validity in adult populations. In this task, participants viewed the movements of triangles, which depicted either action movements, simple interactions, or complex social interactions. Viewing trials with more complex social interactions in the Frith-Happé task was associated with increased brain activation in regions including the right TPJ, the bilateral mPFC, the cerebellum, and the dorsolateral prefrontal cortex. There were no group differences in neural activation in response to the ToM contrast. Overall, these results suggest that the neural basis of spontaneous mentalizing is preserved in most young women with AN. Frontiers Media S.A. 2020-09-10 /pmc/articles/PMC7511528/ /pubmed/33013605 http://dx.doi.org/10.3389/fpsyg.2020.568073 Text en Copyright © 2020 Leslie, Halls, Leppanen, Sedgewick, Smith, Hayward, Lang, Fonville, Simic, Mandy, Nicholls, Murphy, Williams and Tchanturia. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Leslie, Monica
Halls, Daniel
Leppanen, Jenni
Sedgewick, Felicity
Smith, Katherine
Hayward, Hannah
Lang, Katie
Fonville, Leon
Simic, Mima
Mandy, William
Nicholls, Dasha
Murphy, Declan
Williams, Steven
Tchanturia, Kate
Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title_full Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title_fullStr Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title_full_unstemmed Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title_short Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa
title_sort neural correlates of theory of mind are preserved in young women with anorexia nervosa
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511528/
https://www.ncbi.nlm.nih.gov/pubmed/33013605
http://dx.doi.org/10.3389/fpsyg.2020.568073
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