Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model

Type I collagen is the major structural component of lung stroma. Because of its long half-life, type I collagen undergoes post-translational modifications such as glycation during aging process. These modifications have been shown to impact the structural organization of type I collagen fibers. In...

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Detalles Bibliográficos
Autores principales: Sarazin, Thomas, Collin, Guillaume, Buache, Emilie, Van Gulick, Laurence, Charpentier, Céline, Terryn, Christine, Morjani, Hamid, Saby, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549/
https://www.ncbi.nlm.nih.gov/pubmed/33014812
http://dx.doi.org/10.3389/fonc.2020.01593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549/
https://www.ncbi.nlm.nih.gov/pubmed/33014812
http://dx.doi.org/10.3389/fonc.2020.01593

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