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Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface
During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the deci...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511589/ https://www.ncbi.nlm.nih.gov/pubmed/33013876 http://dx.doi.org/10.3389/fimmu.2020.02070 |
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author | Hoo, Regina Nakimuli, Annettee Vento-Tormo, Roser |
author_facet | Hoo, Regina Nakimuli, Annettee Vento-Tormo, Roser |
author_sort | Hoo, Regina |
collection | PubMed |
description | During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the decidual-placental interface, are the first line of defense to avoid vertical transmission. Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. We consider major congenital infections that access the placenta from hematogenous or decidual route. Finally, we highlight the challenges in studying human placental responses to pathogens and vertical transmission using current experimental models and identify gaps in knowledge that need to be addressed. We further propose novel experimental strategies to address such limitations. |
format | Online Article Text |
id | pubmed-7511589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75115892020-10-02 Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface Hoo, Regina Nakimuli, Annettee Vento-Tormo, Roser Front Immunol Immunology During pregnancy, the placenta forms the anatomical barrier between the mother and developing fetus. Infectious agents can potentially breach the placental barrier resulting in pathogenic transmission from mother to fetus. Innate immune responses, orchestrated by maternal and fetal cells at the decidual-placental interface, are the first line of defense to avoid vertical transmission. Here, we outline the anatomy of the human placenta and uterine lining, the decidua, and discuss the potential capacity of pathogen pattern recognition and other host defense strategies present in the innate immune cells at the placental-decidual interface. We consider major congenital infections that access the placenta from hematogenous or decidual route. Finally, we highlight the challenges in studying human placental responses to pathogens and vertical transmission using current experimental models and identify gaps in knowledge that need to be addressed. We further propose novel experimental strategies to address such limitations. Frontiers Media S.A. 2020-09-10 /pmc/articles/PMC7511589/ /pubmed/33013876 http://dx.doi.org/10.3389/fimmu.2020.02070 Text en Copyright © 2020 Hoo, Nakimuli and Vento-Tormo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Hoo, Regina Nakimuli, Annettee Vento-Tormo, Roser Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title_full | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title_fullStr | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title_full_unstemmed | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title_short | Innate Immune Mechanisms to Protect Against Infection at the Human Decidual-Placental Interface |
title_sort | innate immune mechanisms to protect against infection at the human decidual-placental interface |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511589/ https://www.ncbi.nlm.nih.gov/pubmed/33013876 http://dx.doi.org/10.3389/fimmu.2020.02070 |
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