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Structure of the lens and its associations with the visual quality

In humans, the lens is the organ with the ability to change morphology and refractive power, designated as accommodation, to focus light from various distances and obtain clear retinal image. The accommodative ability of the lens depends on its structure and biological parameters. The lens grows thr...

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Autores principales: Ruan, Xiaoting, Liu, Zhenzhen, Luo, Lixia, Liu, Yizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511618/
https://www.ncbi.nlm.nih.gov/pubmed/33024825
http://dx.doi.org/10.1136/bmjophth-2020-000459
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author Ruan, Xiaoting
Liu, Zhenzhen
Luo, Lixia
Liu, Yizhi
author_facet Ruan, Xiaoting
Liu, Zhenzhen
Luo, Lixia
Liu, Yizhi
author_sort Ruan, Xiaoting
collection PubMed
description In humans, the lens is the organ with the ability to change morphology and refractive power, designated as accommodation, to focus light from various distances and obtain clear retinal image. The accommodative ability of the lens depends on its structure and biological parameters. The lens grows throughout the life, forming specific lens sutures and a unique gradient refractive index, and possesses regenerative ability under certain circumstances. Minimally invasive lens surgery that preserves endogenous lens epithelial stem/progenitor cells (LECs) can achieve functional lens regeneration in humans. The lens is the main source of intraocular aberration, especially intraocular higher-order aberrations (IHOAs) which is found to be binocularly symmetrical in phakic eyes. There is a compensation mechanism between corneal aberrations and lens aberrations. Therefore, the structure and the biological parameters of the lens, the binocular relationship of the lens and the correlation between the lens and cornea affect visual quality. This paper summarises the above findings and their current and potential applications in refractive surgeries, providing a comprehensive understanding of the lens as a strong determinant of visual quality in the optical system.
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spelling pubmed-75116182020-10-05 Structure of the lens and its associations with the visual quality Ruan, Xiaoting Liu, Zhenzhen Luo, Lixia Liu, Yizhi BMJ Open Ophthalmol Review In humans, the lens is the organ with the ability to change morphology and refractive power, designated as accommodation, to focus light from various distances and obtain clear retinal image. The accommodative ability of the lens depends on its structure and biological parameters. The lens grows throughout the life, forming specific lens sutures and a unique gradient refractive index, and possesses regenerative ability under certain circumstances. Minimally invasive lens surgery that preserves endogenous lens epithelial stem/progenitor cells (LECs) can achieve functional lens regeneration in humans. The lens is the main source of intraocular aberration, especially intraocular higher-order aberrations (IHOAs) which is found to be binocularly symmetrical in phakic eyes. There is a compensation mechanism between corneal aberrations and lens aberrations. Therefore, the structure and the biological parameters of the lens, the binocular relationship of the lens and the correlation between the lens and cornea affect visual quality. This paper summarises the above findings and their current and potential applications in refractive surgeries, providing a comprehensive understanding of the lens as a strong determinant of visual quality in the optical system. BMJ Publishing Group 2020-09-18 /pmc/articles/PMC7511618/ /pubmed/33024825 http://dx.doi.org/10.1136/bmjophth-2020-000459 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Ruan, Xiaoting
Liu, Zhenzhen
Luo, Lixia
Liu, Yizhi
Structure of the lens and its associations with the visual quality
title Structure of the lens and its associations with the visual quality
title_full Structure of the lens and its associations with the visual quality
title_fullStr Structure of the lens and its associations with the visual quality
title_full_unstemmed Structure of the lens and its associations with the visual quality
title_short Structure of the lens and its associations with the visual quality
title_sort structure of the lens and its associations with the visual quality
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511618/
https://www.ncbi.nlm.nih.gov/pubmed/33024825
http://dx.doi.org/10.1136/bmjophth-2020-000459
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