Efficient Cocaine Degradation by Cocaine Esterase-Loaded Red Blood Cells

Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, although improving in vitro thermo-stability and in...

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Detalles Bibliográficos
Autores principales: Rossi, Luigia, Pierigè, Francesca, Agostini, Marco, Bigini, Noemi, Termopoli, Veronica, Cai, Yingting, Zheng, Fang, Zhan, Chang-Guo, Landry, Donald W., Magnani, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511699/
https://www.ncbi.nlm.nih.gov/pubmed/33013487
http://dx.doi.org/10.3389/fphys.2020.573492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511699/
https://www.ncbi.nlm.nih.gov/pubmed/33013487
http://dx.doi.org/10.3389/fphys.2020.573492

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