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Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain

Human MIA40, an intermembrane space (IMS) import receptor of mitochondria harbors twin CX9C motifs for stability while its CPC motif is known to facilitate the import of IMS bound proteins. Site-directed mutagenesis complemented by MALDI on in vivo hMIA40 protein shows that a portion of MIA40 underg...

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Detalles Bibliográficos
Autores principales: Thiriveedi, Venkata Ramana, Mattam, Ushodaya, Pattabhi, Prasad, Bisoyi, Vandana, Talari, Noble Kumar, Krishnamoorthy, Thanuja, Sepuri, Naresh Babu V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511737/
https://www.ncbi.nlm.nih.gov/pubmed/32971361
http://dx.doi.org/10.1016/j.redox.2020.101725