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Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma

Primary mediastinal B‐cell lymphoma (PMBCL) is a rare tumour with different characteristics from other type of lymphomas. Clinical manifestations may vary and cause delay in diagnosis and management. We present a 22‐year‐old patient with symptoms of shortness of breath, weight loss, and night sweats...

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Autores principales: Rajabto, Wulyo, Priantono, Dimas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511779/
https://www.ncbi.nlm.nih.gov/pubmed/33005424
http://dx.doi.org/10.1002/rcr2.668
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author Rajabto, Wulyo
Priantono, Dimas
author_facet Rajabto, Wulyo
Priantono, Dimas
author_sort Rajabto, Wulyo
collection PubMed
description Primary mediastinal B‐cell lymphoma (PMBCL) is a rare tumour with different characteristics from other type of lymphomas. Clinical manifestations may vary and cause delay in diagnosis and management. We present a 22‐year‐old patient with symptoms of shortness of breath, weight loss, and night sweats. Laboratory studies only showed a markedly high lactate dehydrogenase (LDH) level and thoracic computed tomography (CT)scan revealed a large mediastinal mass. Core biopsy‐guided CT scan was performed and the pathological and immunohistochemistry established a PMBCL diagnosis. We administered Rituximab Dose‐Adjusted Etoposide Prednisolone Vincristine Cyclophosphamide Doxorubicin (R‐DA‐EPOCH) chemotherapy regimen and the patient responded well to treatment. This is an example of rare case of mediastinal lymphoma with challenges to overcome to achieve diagnostic and therapeutic success. Failure to differentiate PMBCL with other systemic diffuse large B‐cell lymphoma (DLBCL) could skew treatment algorithm and prevent optimal response. Administration of proper systemic therapy, especially in young, low‐risk patients could yield excellent outcome.
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spelling pubmed-75117792020-09-30 Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma Rajabto, Wulyo Priantono, Dimas Respirol Case Rep Case Reports Primary mediastinal B‐cell lymphoma (PMBCL) is a rare tumour with different characteristics from other type of lymphomas. Clinical manifestations may vary and cause delay in diagnosis and management. We present a 22‐year‐old patient with symptoms of shortness of breath, weight loss, and night sweats. Laboratory studies only showed a markedly high lactate dehydrogenase (LDH) level and thoracic computed tomography (CT)scan revealed a large mediastinal mass. Core biopsy‐guided CT scan was performed and the pathological and immunohistochemistry established a PMBCL diagnosis. We administered Rituximab Dose‐Adjusted Etoposide Prednisolone Vincristine Cyclophosphamide Doxorubicin (R‐DA‐EPOCH) chemotherapy regimen and the patient responded well to treatment. This is an example of rare case of mediastinal lymphoma with challenges to overcome to achieve diagnostic and therapeutic success. Failure to differentiate PMBCL with other systemic diffuse large B‐cell lymphoma (DLBCL) could skew treatment algorithm and prevent optimal response. Administration of proper systemic therapy, especially in young, low‐risk patients could yield excellent outcome. John Wiley & Sons, Ltd 2020-09-24 /pmc/articles/PMC7511779/ /pubmed/33005424 http://dx.doi.org/10.1002/rcr2.668 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Rajabto, Wulyo
Priantono, Dimas
Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title_full Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title_fullStr Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title_full_unstemmed Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title_short Primary CD20‐positive mediastinal diffuse large B‐cell lymphoma
title_sort primary cd20‐positive mediastinal diffuse large b‐cell lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511779/
https://www.ncbi.nlm.nih.gov/pubmed/33005424
http://dx.doi.org/10.1002/rcr2.668
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