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Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article

BACKGROUND: Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced gly...

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Autores principales: Tommy, Thomas, Islam, Andi A., Hatta, Mochammad, Bukhari, Agussalim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511818/
https://www.ncbi.nlm.nih.gov/pubmed/32994992
http://dx.doi.org/10.1016/j.amsu.2020.09.025
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author Tommy, Thomas
Islam, Andi A.
Hatta, Mochammad
Bukhari, Agussalim
author_facet Tommy, Thomas
Islam, Andi A.
Hatta, Mochammad
Bukhari, Agussalim
author_sort Tommy, Thomas
collection PubMed
description BACKGROUND: Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced glycation end products (RAGE), will cause positive amplification of inflammation signalling pathway. Brain injury is one of the major contributors for disability and death which neuroinflammation has a major role in its pathogenesis and influencing its outcome. In neuroinflammation, it has been described that HMGB1 may have a pivotal role in the process. OBJECTIVE: The objective of this article is to review the role HMGB1 in brain injury and its immunomodulatory properties. METHODS: A comprehensive search of literature was conducted in PubMed (NIH), Scopus, EMBASE, and Google Scholar database using keyword combinations of the medical subject headings (MeSH) of “HMGB1” and “Brain Injury” and relevant reference lists were also manually searched. All relevant articles of any study design published from year 1990 till June 2020, were included and narratively discussed in this review. RESULTS: Twenty-four articles were shortlisted and reviewed in this article. Through these articles, we synthesis information on the function and metabolism of HMGB1, immunomodulatory effect of HMGB1, clinical findings and other potential treatment involving HMGB1, and role of HMGB1 protein in brain injury. CONCLUSION: HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways.Review registration number reviewregistry966 in www.researchregistry.com.
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spelling pubmed-75118182020-09-28 Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article Tommy, Thomas Islam, Andi A. Hatta, Mochammad Bukhari, Agussalim Ann Med Surg (Lond) Review BACKGROUND: Human mobility group box 1 (HMGB1) is a novel biomolecular agent which has a major part in inflammation process. HMGB1 has been known to be a strong pro-inflammatory factor as damage associated molecular pattern (DAMP) which its interaction with its receptor, the receptor of advanced glycation end products (RAGE), will cause positive amplification of inflammation signalling pathway. Brain injury is one of the major contributors for disability and death which neuroinflammation has a major role in its pathogenesis and influencing its outcome. In neuroinflammation, it has been described that HMGB1 may have a pivotal role in the process. OBJECTIVE: The objective of this article is to review the role HMGB1 in brain injury and its immunomodulatory properties. METHODS: A comprehensive search of literature was conducted in PubMed (NIH), Scopus, EMBASE, and Google Scholar database using keyword combinations of the medical subject headings (MeSH) of “HMGB1” and “Brain Injury” and relevant reference lists were also manually searched. All relevant articles of any study design published from year 1990 till June 2020, were included and narratively discussed in this review. RESULTS: Twenty-four articles were shortlisted and reviewed in this article. Through these articles, we synthesis information on the function and metabolism of HMGB1, immunomodulatory effect of HMGB1, clinical findings and other potential treatment involving HMGB1, and role of HMGB1 protein in brain injury. CONCLUSION: HMGB1 has a strong pro-inflammation property which predominantly acts through RAGE pathways.Review registration number reviewregistry966 in www.researchregistry.com. Elsevier 2020-09-20 /pmc/articles/PMC7511818/ /pubmed/32994992 http://dx.doi.org/10.1016/j.amsu.2020.09.025 Text en © 2020 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tommy, Thomas
Islam, Andi A.
Hatta, Mochammad
Bukhari, Agussalim
Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title_full Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title_fullStr Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title_full_unstemmed Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title_short Immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: Review article
title_sort immunomodulatory properties of high mobility group box 1 and its potential role in brain injury: review article
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511818/
https://www.ncbi.nlm.nih.gov/pubmed/32994992
http://dx.doi.org/10.1016/j.amsu.2020.09.025
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