Tau‐induced upregulation of C/EBPβ‐TRPC1‐SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration

Intracellular accumulating of the hyperphosphorylated tau plays a pivotal role in neurodegeneration of Alzheimer disease (AD), but the mechanisms underlying the gradually aggravated tau hyperphosphorylation remain elusive. Here, we show that increasing intracellular tau could upregulate mRNA and pro...

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Detalles Bibliográficos
Autores principales: Ye, Jinwang, Yin, Ying, Yin, Yaling, Zhang, Huaqiu, Wan, Huali, Wang, Lu, Zuo, Yue, Gao, Di, Li, Mengzhu, Li, Jun, Liu, Yanchao, Ke, Dan, Wang, Jian‐Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511862/
https://www.ncbi.nlm.nih.gov/pubmed/32815315
http://dx.doi.org/10.1111/acel.13209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511862/
https://www.ncbi.nlm.nih.gov/pubmed/32815315
http://dx.doi.org/10.1111/acel.13209

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