Cargando…
CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging
Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neuroge...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511866/ https://www.ncbi.nlm.nih.gov/pubmed/32741087 http://dx.doi.org/10.1111/acel.13198 |
_version_ | 1783586042751746048 |
---|---|
author | Moreno‐Valladares, Manuel Moreno‐Cugnon, Leire Silva, Tulio Mateo Garcés, Juan Pablo Saenz‐Antoñanzas, Ander Álvarez‐Satta, María Matheu, Ander |
author_facet | Moreno‐Valladares, Manuel Moreno‐Cugnon, Leire Silva, Tulio Mateo Garcés, Juan Pablo Saenz‐Antoñanzas, Ander Álvarez‐Satta, María Matheu, Ander |
author_sort | Moreno‐Valladares, Manuel |
collection | PubMed |
description | Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T‐cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3(+) and CD8(+) T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3(+) and CD8(+) T cells in the SVZ of individuals with neurodegenerative diseases. However, T‐cell count was similar when compared non‐neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non‐pathological conditions and also in neurodegenerative contexts. |
format | Online Article Text |
id | pubmed-7511866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75118662020-09-30 CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging Moreno‐Valladares, Manuel Moreno‐Cugnon, Leire Silva, Tulio Mateo Garcés, Juan Pablo Saenz‐Antoñanzas, Ander Álvarez‐Satta, María Matheu, Ander Aging Cell Original Articles Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs in human neurogenic niches or to which extent T‐cell infiltration is also taking place in neurodegenerative diseases remains unknown. In this work, we studied the presence of T cells in both human neurogenic niches in young and old individuals. There was a significant increase in the number of CD3(+) and CD8(+) T cells in the SVZ of elderly individuals, which was not detected in the dentate gyrus. Moreover, we also found CD3(+) and CD8(+) T cells in the SVZ of individuals with neurodegenerative diseases. However, T‐cell count was similar when compared non‐neuropathological elderly with disease diagnosed patients. Our study reveals the infiltration of T cells in old human brains, particularly in the SVZ under non‐pathological conditions and also in neurodegenerative contexts. John Wiley and Sons Inc. 2020-08-01 2020-09 /pmc/articles/PMC7511866/ /pubmed/32741087 http://dx.doi.org/10.1111/acel.13198 Text en © 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Moreno‐Valladares, Manuel Moreno‐Cugnon, Leire Silva, Tulio Mateo Garcés, Juan Pablo Saenz‐Antoñanzas, Ander Álvarez‐Satta, María Matheu, Ander CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title | CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title_full | CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title_fullStr | CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title_full_unstemmed | CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title_short | CD8(+) T cells are increased in the subventricular zone with physiological and pathological aging |
title_sort | cd8(+) t cells are increased in the subventricular zone with physiological and pathological aging |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511866/ https://www.ncbi.nlm.nih.gov/pubmed/32741087 http://dx.doi.org/10.1111/acel.13198 |
work_keys_str_mv | AT morenovalladaresmanuel cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT morenocugnonleire cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT silvatuliomateo cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT garcesjuanpablo cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT saenzantonanzasander cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT alvarezsattamaria cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging AT matheuander cd8tcellsareincreasedinthesubventricularzonewithphysiologicalandpathologicalaging |