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The S-nitrosylation of parkin attenuated the ubiquitination of divalent metal transporter 1 in MPP(+)-treated SH-SY5Y cells

Abnormal iron accumulation caused by elevated levels of divalent metal transporter 1 (DMT1) contributes to progressive neurodegeneration in Parkinson's disease (PD). Parkin is a E3 ubiquitin ligase for the ubiquitination of DMT1. S-nitrosylated parkin (SNO-parkin) is commonly observed in PD. Ho...

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Detalles Bibliográficos
Autores principales:	Zhong, Yanmin, Li, Xin, Du, Xixun, Bi, Mingxia, Ma, Fengtong, Xie, Junxia, Jiang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511936/ https://www.ncbi.nlm.nih.gov/pubmed/32968192 http://dx.doi.org/10.1038/s41598-020-72630-2

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