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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth

Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing...

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Autores principales: Krivanek, Jan, Soldatov, Ruslan A., Kastriti, Maria Eleni, Chontorotzea, Tatiana, Herdina, Anna Nele, Petersen, Julian, Szarowska, Bara, Landova, Marie, Matejova, Veronika Kovar, Holla, Lydie Izakovicova, Kuchler, Ulrike, Zdrilic, Ivana Vidovic, Vijaykumar, Anushree, Balic, Anamaria, Marangoni, Pauline, Klein, Ophir D., Neves, Vitor C. M., Yianni, Val, Sharpe, Paul T., Harkany, Tibor, Metscher, Brian D., Bajénoff, Marc, Mina, Mina, Fried, Kaj, Kharchenko, Peter V., Adameyko, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511944/
https://www.ncbi.nlm.nih.gov/pubmed/32968047
http://dx.doi.org/10.1038/s41467-020-18512-7
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author Krivanek, Jan
Soldatov, Ruslan A.
Kastriti, Maria Eleni
Chontorotzea, Tatiana
Herdina, Anna Nele
Petersen, Julian
Szarowska, Bara
Landova, Marie
Matejova, Veronika Kovar
Holla, Lydie Izakovicova
Kuchler, Ulrike
Zdrilic, Ivana Vidovic
Vijaykumar, Anushree
Balic, Anamaria
Marangoni, Pauline
Klein, Ophir D.
Neves, Vitor C. M.
Yianni, Val
Sharpe, Paul T.
Harkany, Tibor
Metscher, Brian D.
Bajénoff, Marc
Mina, Mina
Fried, Kaj
Kharchenko, Peter V.
Adameyko, Igor
author_facet Krivanek, Jan
Soldatov, Ruslan A.
Kastriti, Maria Eleni
Chontorotzea, Tatiana
Herdina, Anna Nele
Petersen, Julian
Szarowska, Bara
Landova, Marie
Matejova, Veronika Kovar
Holla, Lydie Izakovicova
Kuchler, Ulrike
Zdrilic, Ivana Vidovic
Vijaykumar, Anushree
Balic, Anamaria
Marangoni, Pauline
Klein, Ophir D.
Neves, Vitor C. M.
Yianni, Val
Sharpe, Paul T.
Harkany, Tibor
Metscher, Brian D.
Bajénoff, Marc
Mina, Mina
Fried, Kaj
Kharchenko, Peter V.
Adameyko, Igor
author_sort Krivanek, Jan
collection PubMed
description Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation.
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spelling pubmed-75119442020-10-08 Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth Krivanek, Jan Soldatov, Ruslan A. Kastriti, Maria Eleni Chontorotzea, Tatiana Herdina, Anna Nele Petersen, Julian Szarowska, Bara Landova, Marie Matejova, Veronika Kovar Holla, Lydie Izakovicova Kuchler, Ulrike Zdrilic, Ivana Vidovic Vijaykumar, Anushree Balic, Anamaria Marangoni, Pauline Klein, Ophir D. Neves, Vitor C. M. Yianni, Val Sharpe, Paul T. Harkany, Tibor Metscher, Brian D. Bajénoff, Marc Mina, Mina Fried, Kaj Kharchenko, Peter V. Adameyko, Igor Nat Commun Article Understanding cell types and mechanisms of dental growth is essential for reconstruction and engineering of teeth. Therefore, we investigated cellular composition of growing and non-growing mouse and human teeth. As a result, we report an unappreciated cellular complexity of the continuously-growing mouse incisor, which suggests a coherent model of cell dynamics enabling unarrested growth. This model relies on spatially-restricted stem, progenitor and differentiated populations in the epithelial and mesenchymal compartments underlying the coordinated expansion of two major branches of pulpal cells and diverse epithelial subtypes. Further comparisons of human and mouse teeth yield both parallelisms and differences in tissue heterogeneity and highlight the specifics behind growing and non-growing modes. Despite being similar at a coarse level, mouse and human teeth reveal molecular differences and species-specific cell subtypes suggesting possible evolutionary divergence. Overall, here we provide an atlas of human and mouse teeth with a focus on growth and differentiation. Nature Publishing Group UK 2020-09-23 /pmc/articles/PMC7511944/ /pubmed/32968047 http://dx.doi.org/10.1038/s41467-020-18512-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Krivanek, Jan
Soldatov, Ruslan A.
Kastriti, Maria Eleni
Chontorotzea, Tatiana
Herdina, Anna Nele
Petersen, Julian
Szarowska, Bara
Landova, Marie
Matejova, Veronika Kovar
Holla, Lydie Izakovicova
Kuchler, Ulrike
Zdrilic, Ivana Vidovic
Vijaykumar, Anushree
Balic, Anamaria
Marangoni, Pauline
Klein, Ophir D.
Neves, Vitor C. M.
Yianni, Val
Sharpe, Paul T.
Harkany, Tibor
Metscher, Brian D.
Bajénoff, Marc
Mina, Mina
Fried, Kaj
Kharchenko, Peter V.
Adameyko, Igor
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title_full Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title_fullStr Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title_full_unstemmed Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title_short Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
title_sort dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511944/
https://www.ncbi.nlm.nih.gov/pubmed/32968047
http://dx.doi.org/10.1038/s41467-020-18512-7
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