The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding

MICA/B proteins are expressed on the surface of various types of stressed cells, including cancer cells. Cytotoxic lymphocytes expressing natural killer group 2D (NKG2D) receptor recognize MICA/B and eliminate the cells. However, cancer cells evade such immune recognition by inducing proteolytic she...

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Detalles Bibliográficos
Autores principales: Sekiba, Kazuma, Otsuka, Motoyuki, Seimiya, Takahiro, Tanaka, Eri, Funato, Kazuyoshi, Miyakawa, Yu, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512021/
https://www.ncbi.nlm.nih.gov/pubmed/32968163
http://dx.doi.org/10.1038/s41598-020-72688-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512021/
https://www.ncbi.nlm.nih.gov/pubmed/32968163
http://dx.doi.org/10.1038/s41598-020-72688-y

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