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Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis

Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide. Factors like cellular senescence, genetic...

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Autores principales: Khatana, Chainika, Saini, Neeraj K., Chakrabarti, Sasanka, Saini, Vipin, Sharma, Anil, Saini, Reena V., Saini, Adesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512065/
https://www.ncbi.nlm.nih.gov/pubmed/33014272
http://dx.doi.org/10.1155/2020/5245308
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author Khatana, Chainika
Saini, Neeraj K.
Chakrabarti, Sasanka
Saini, Vipin
Sharma, Anil
Saini, Reena V.
Saini, Adesh K.
author_facet Khatana, Chainika
Saini, Neeraj K.
Chakrabarti, Sasanka
Saini, Vipin
Sharma, Anil
Saini, Reena V.
Saini, Adesh K.
author_sort Khatana, Chainika
collection PubMed
description Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide. Factors like cellular senescence, genetics, clonal haematopoiesis, sedentary lifestyle-induced obesity, or diabetes mellitus upsurge the tendency of atherosclerosis and are foremost pioneers to definitive transience. Accumulation of oxidized low-density lipoproteins (Ox-LDLs) in the tunica intima triggers the onset of this disease. In the later period of progression, the build-up plaques rupture ensuing thrombosis (completely blocking the blood flow), causing myocardial infarction, stroke, and heart attack, all of which are common atherosclerotic cardiovascular events today. The underlying mechanism is very well elucidated in literature but the therapeutic measures remains to be unleashed. Researchers tussle to demonstrate a clear understanding of treating mechanisms. A century of research suggests that lowering LDL, statin-mediated treatment, HDL, and lipid-profile management should be of prime interest to retard atherosclerosis-induced deaths. We shall brief the Ox-LDL-induced atherogenic mechanism and the treating measures in line to impede the development and progression of atherosclerosis.
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spelling pubmed-75120652020-10-02 Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis Khatana, Chainika Saini, Neeraj K. Chakrabarti, Sasanka Saini, Vipin Sharma, Anil Saini, Reena V. Saini, Adesh K. Oxid Med Cell Longev Review Article Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of medium to large arteries. Atherosclerosis is the prime root of cardiovascular events contributing to the most considerable number of morbidity and mortality worldwide. Factors like cellular senescence, genetics, clonal haematopoiesis, sedentary lifestyle-induced obesity, or diabetes mellitus upsurge the tendency of atherosclerosis and are foremost pioneers to definitive transience. Accumulation of oxidized low-density lipoproteins (Ox-LDLs) in the tunica intima triggers the onset of this disease. In the later period of progression, the build-up plaques rupture ensuing thrombosis (completely blocking the blood flow), causing myocardial infarction, stroke, and heart attack, all of which are common atherosclerotic cardiovascular events today. The underlying mechanism is very well elucidated in literature but the therapeutic measures remains to be unleashed. Researchers tussle to demonstrate a clear understanding of treating mechanisms. A century of research suggests that lowering LDL, statin-mediated treatment, HDL, and lipid-profile management should be of prime interest to retard atherosclerosis-induced deaths. We shall brief the Ox-LDL-induced atherogenic mechanism and the treating measures in line to impede the development and progression of atherosclerosis. Hindawi 2020-09-15 /pmc/articles/PMC7512065/ /pubmed/33014272 http://dx.doi.org/10.1155/2020/5245308 Text en Copyright © 2020 Chainika Khatana et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khatana, Chainika
Saini, Neeraj K.
Chakrabarti, Sasanka
Saini, Vipin
Sharma, Anil
Saini, Reena V.
Saini, Adesh K.
Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title_full Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title_fullStr Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title_full_unstemmed Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title_short Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
title_sort mechanistic insights into the oxidized low-density lipoprotein-induced atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512065/
https://www.ncbi.nlm.nih.gov/pubmed/33014272
http://dx.doi.org/10.1155/2020/5245308
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