Cargando…

A Novel Signature Based on mTORC1 Pathway in Hepatocellular Carcinoma

BACKGROUND: mTORC1 signal pathway plays a role in the initiation and progression of hepatocellular carcinoma (HCC), but no relevant gene signature was developed. This research aimed to explore the potential correlation between the mTORC1 signal pathway and HCC and establish the related gene signatur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mo, Zhuomao, Zhang, Shuqiao, Zhang, Shijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512110/ https://www.ncbi.nlm.nih.gov/pubmed/33014055 http://dx.doi.org/10.1155/2020/8291036

Ejemplares similares

A novel hepatocellular carcinoma-specific mTORC1-related signature for anticipating prognosis and immunotherapy
por: Chen, Erbao, et al.
Publicado: (2023)

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma
por: Li, Ting, et al.
Publicado: (2020)

A Network Pharmacology Approach to Reveal the Underlying Mechanisms of Artemisia annua on the Treatment of Hepatocellular Carcinoma
por: Zhang, Shuqiao, et al.
Publicado: (2021)

PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2
por: Chen, Qiongfeng, et al.
Publicado: (2022)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Crosstalk of Hedgehog and mTORC1 Pathways
por: Larsen, Lasse Jonsgaard, et al.
Publicado: (2020)

Novel Molecular Subtypes Associated With 5mC Methylation and Their Role in Hepatocellular Carcinoma Immunotherapy
por: Mo, Zhuomao, et al.
Publicado: (2020)

BUB1B promotes hepatocellular carcinoma progression via activation of the mTORC1 signaling pathway
por: Qiu, Jiannan, et al.
Publicado: (2020)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Targeting mTORC1/2 Complexes Inhibit Tumorigenesis and Enhance Sensitivity to 5-Flourouracil (5-FU) in Hepatocellular Carcinoma: A Preclinical Study of mTORC1/2-Targeted Therapy in Hepatocellular Carcinoma (HCC)
por: Zhang, Yu, et al.
Publicado: (2018)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

mTORC1 signaling pathway regulates tooth repair
por: Liu, Honghong, et al.
Publicado: (2023)

The Role of mTORC1 Pathway and Autophagy in Resistance to Platinum-Based Chemotherapeutics
por: Pan, Zhenrui, et al.
Publicado: (2023)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Modulation of mTORC1 Signaling Pathway by HIV-1
por: Akbay, Burkitkan, et al.
Publicado: (2020)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia
por: Kawata, Takahito, et al.
Publicado: (2017)

Hypoxic Characteristic in the Immunosuppressive Microenvironment of Hepatocellular Carcinoma
por: Mo, Zhuomao, et al.
Publicado: (2021)

Regulation of bone formation by baicalein via the mTORC1 pathway
por: Li, Sheng-fa, et al.
Publicado: (2015)

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis
por: Gong, Sa, et al.
Publicado: (2023)

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
por: Wang, Fangjie, et al.
Publicado: (2018)

A Comparison of Ku0063794, a Dual mTORC1 and mTORC2 Inhibitor, and Temsirolimus in Preclinical Renal Cell Carcinoma Models
por: Zhang, Hao, et al.
Publicado: (2013)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma
por: Wang, Quan, et al.
Publicado: (2013)

Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo
por: Pan, Xiao-dong, et al.
Publicado: (2017)

Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
por: Xu, Zhong, et al.
Publicado: (2018)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
por: Chen, Yingji, et al.
Publicado: (2023)

mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 and mTORC2 Complexes for Tumor Behavior and SLC5A5 mRNA Expression
por: Tavares, Catarina, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9ri9e8l3k16evfqv9mpdeufic6