Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19

In the article “The pathophysiology of ‘happy’ hypoxemia in COVID-19,” Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patients with COVID-19 who exhibit severe hypoxemia. The authors review well-known mechanisms that...

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Autores principales: Tobin, Martin J., Jubran, Amal, Laghi, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512214/
https://www.ncbi.nlm.nih.gov/pubmed/32972411
http://dx.doi.org/10.1186/s12931-020-01520-y
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author Tobin, Martin J.
Jubran, Amal
Laghi, Franco
author_facet Tobin, Martin J.
Jubran, Amal
Laghi, Franco
author_sort Tobin, Martin J.
collection PubMed
description In the article “The pathophysiology of ‘happy’ hypoxemia in COVID-19,” Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patients with COVID-19 who exhibit severe hypoxemia. The authors review well-known mechanisms that contribute to development of hypoxemia in patients with pneumonia, but are less clear as to why patients should be free of respiratory discomfort despite arterial oxygen levels commonly regarded as life threatening. The authors propose a number of therapeutic measures for patients with COVID-19 and happy hypoxemia; we believe readers should be alerted to problems with the authors’ interpretations and recommendations.
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spelling pubmed-75122142020-09-24 Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19 Tobin, Martin J. Jubran, Amal Laghi, Franco Respir Res Letter to the Editor In the article “The pathophysiology of ‘happy’ hypoxemia in COVID-19,” Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patients with COVID-19 who exhibit severe hypoxemia. The authors review well-known mechanisms that contribute to development of hypoxemia in patients with pneumonia, but are less clear as to why patients should be free of respiratory discomfort despite arterial oxygen levels commonly regarded as life threatening. The authors propose a number of therapeutic measures for patients with COVID-19 and happy hypoxemia; we believe readers should be alerted to problems with the authors’ interpretations and recommendations. BioMed Central 2020-09-24 2020 /pmc/articles/PMC7512214/ /pubmed/32972411 http://dx.doi.org/10.1186/s12931-020-01520-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Tobin, Martin J.
Jubran, Amal
Laghi, Franco
Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title_full Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title_fullStr Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title_full_unstemmed Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title_short Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
title_sort misconceptions of pathophysiology of happy hypoxemia and implications for management of covid-19
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512214/
https://www.ncbi.nlm.nih.gov/pubmed/32972411
http://dx.doi.org/10.1186/s12931-020-01520-y
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