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Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics
We propose a dynamical system of tumor cells proliferation based on operatorial methods. The approach we propose is quantum-like: we use ladder and number operators to describe healthy and tumor cells birth and death, and the evolution is ruled by a non-hermitian Hamiltonian which includes, in a non...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512787/ https://www.ncbi.nlm.nih.gov/pubmed/33265361 http://dx.doi.org/10.3390/e20040270 |
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author | Bagarello, Fabio Gargano, Francesco |
author_facet | Bagarello, Fabio Gargano, Francesco |
author_sort | Bagarello, Fabio |
collection | PubMed |
description | We propose a dynamical system of tumor cells proliferation based on operatorial methods. The approach we propose is quantum-like: we use ladder and number operators to describe healthy and tumor cells birth and death, and the evolution is ruled by a non-hermitian Hamiltonian which includes, in a non reversible way, the basic biological mechanisms we consider for the system. We show that this approach is rather efficient in describing some processes of the cells. We further add some medical treatment, described by adding a suitable term in the Hamiltonian, which controls and limits the growth of tumor cells, and we propose an optimal approach to stop, and reverse, this growth. |
format | Online Article Text |
id | pubmed-7512787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75127872020-11-09 Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics Bagarello, Fabio Gargano, Francesco Entropy (Basel) Article We propose a dynamical system of tumor cells proliferation based on operatorial methods. The approach we propose is quantum-like: we use ladder and number operators to describe healthy and tumor cells birth and death, and the evolution is ruled by a non-hermitian Hamiltonian which includes, in a non reversible way, the basic biological mechanisms we consider for the system. We show that this approach is rather efficient in describing some processes of the cells. We further add some medical treatment, described by adding a suitable term in the Hamiltonian, which controls and limits the growth of tumor cells, and we propose an optimal approach to stop, and reverse, this growth. MDPI 2018-04-11 /pmc/articles/PMC7512787/ /pubmed/33265361 http://dx.doi.org/10.3390/e20040270 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bagarello, Fabio Gargano, Francesco Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title | Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title_full | Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title_fullStr | Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title_full_unstemmed | Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title_short | Non-Hermitian Operator Modelling of Basic Cancer Cell Dynamics |
title_sort | non-hermitian operator modelling of basic cancer cell dynamics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7512787/ https://www.ncbi.nlm.nih.gov/pubmed/33265361 http://dx.doi.org/10.3390/e20040270 |
work_keys_str_mv | AT bagarellofabio nonhermitianoperatormodellingofbasiccancercelldynamics AT garganofrancesco nonhermitianoperatormodellingofbasiccancercelldynamics |