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Hemodialysis patients with low serum parathyroid hormone levels have a poorer prognosis than those with secondary hyperparathyroidism
BACKGROUND: Low serum parathyroid hormone (PTH) level and secondary hyperparathyroidism (SHPT) are very common in hemodialysis patients. However, the outcomes of patients with low PTH level or SHPT have not been carefully compared. Therefore, in the present study, we compared the outcomes of hemodia...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513009/ https://www.ncbi.nlm.nih.gov/pubmed/33014329 http://dx.doi.org/10.1177/2042018820958322 |
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author | Yu, Yue Diao, Zongli Wang, Ying Zhou, Peiyi Ding, Rui Liu, Wenhu |
author_facet | Yu, Yue Diao, Zongli Wang, Ying Zhou, Peiyi Ding, Rui Liu, Wenhu |
author_sort | Yu, Yue |
collection | PubMed |
description | BACKGROUND: Low serum parathyroid hormone (PTH) level and secondary hyperparathyroidism (SHPT) are very common in hemodialysis patients. However, the outcomes of patients with low PTH level or SHPT have not been carefully compared. Therefore, in the present study, we compared the outcomes of hemodialysis patients with low PTH level or SHPT. METHODS: This was a multi-center, prospective, cohort study of 647 patients. The patients were recruited between 1 September 2016 and 1 January 2017 and followed until 31 December 2018. The participants were allocated to a low PTH group [serum intact PTH (iPTH) concentration < 60 pg/ml] and an SHPT group (iPTH ⩾ 600 pg/ml) according to their mean iPTH concentration across the entire observation period, and the outcomes were compared between these groups. The primary outcome was a composite outcome, which comprised all-cause mortality, non-fatal acute myocardial infarction, non-fatal acute stroke, and acute heart failure. RESULTS: A total of 197 hemodialysis patients were allocated to the two groups: 87 with low PTH level and 110 with SHPT; 450 patients with time-averaged iPTH concentrations of 60–600 pg/ml were excluded. Kaplan–Meier analysis of the composite endpoint revealed a significant difference between participants with low PTH level and those with SHPT (p = 0.002). Cox multiple regression showed that participants with low PTH level had a higher incidence of the composite endpoint than those with SHPT (relative risk: 1.337, 95% confidence interval: 1.059–1.688). CONCLUSION: Hemodialysis patients with low PTH level had a higher incidence of mortality and non-fatal cardiovascular events than those with SHPT, irrespective of whether the participants were age-matched. |
format | Online Article Text |
id | pubmed-7513009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-75130092020-10-01 Hemodialysis patients with low serum parathyroid hormone levels have a poorer prognosis than those with secondary hyperparathyroidism Yu, Yue Diao, Zongli Wang, Ying Zhou, Peiyi Ding, Rui Liu, Wenhu Ther Adv Endocrinol Metab Original Research BACKGROUND: Low serum parathyroid hormone (PTH) level and secondary hyperparathyroidism (SHPT) are very common in hemodialysis patients. However, the outcomes of patients with low PTH level or SHPT have not been carefully compared. Therefore, in the present study, we compared the outcomes of hemodialysis patients with low PTH level or SHPT. METHODS: This was a multi-center, prospective, cohort study of 647 patients. The patients were recruited between 1 September 2016 and 1 January 2017 and followed until 31 December 2018. The participants were allocated to a low PTH group [serum intact PTH (iPTH) concentration < 60 pg/ml] and an SHPT group (iPTH ⩾ 600 pg/ml) according to their mean iPTH concentration across the entire observation period, and the outcomes were compared between these groups. The primary outcome was a composite outcome, which comprised all-cause mortality, non-fatal acute myocardial infarction, non-fatal acute stroke, and acute heart failure. RESULTS: A total of 197 hemodialysis patients were allocated to the two groups: 87 with low PTH level and 110 with SHPT; 450 patients with time-averaged iPTH concentrations of 60–600 pg/ml were excluded. Kaplan–Meier analysis of the composite endpoint revealed a significant difference between participants with low PTH level and those with SHPT (p = 0.002). Cox multiple regression showed that participants with low PTH level had a higher incidence of the composite endpoint than those with SHPT (relative risk: 1.337, 95% confidence interval: 1.059–1.688). CONCLUSION: Hemodialysis patients with low PTH level had a higher incidence of mortality and non-fatal cardiovascular events than those with SHPT, irrespective of whether the participants were age-matched. SAGE Publications 2020-09-21 /pmc/articles/PMC7513009/ /pubmed/33014329 http://dx.doi.org/10.1177/2042018820958322 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Yu, Yue Diao, Zongli Wang, Ying Zhou, Peiyi Ding, Rui Liu, Wenhu Hemodialysis patients with low serum parathyroid hormone levels have a poorer prognosis than those with secondary hyperparathyroidism |
title | Hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
title_full | Hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
title_fullStr | Hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
title_full_unstemmed | Hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
title_short | Hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
title_sort | hemodialysis patients with low serum parathyroid hormone levels have
a poorer prognosis than those with secondary hyperparathyroidism |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513009/ https://www.ncbi.nlm.nih.gov/pubmed/33014329 http://dx.doi.org/10.1177/2042018820958322 |
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