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Regio- and Stereoselective Synthesis of the Core Structure of Hexahydrobenzo[c]phenanthridine Alkaloids via Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation of Cyclic Alkenes with Benzamides
[Image: see text] A highly stereo- and regioselective synthesis of the core skeleton of hexahydrobenzo[c]phenanthridine-type alkaloids is reported herein for the first time. A wide range of substrate scope, excellent functional group tolerance, and good to excellent yields were observed. This protoc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513371/ https://www.ncbi.nlm.nih.gov/pubmed/32984725 http://dx.doi.org/10.1021/acsomega.0c03434 |
| _version_ | 1783586371871440896 |
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| author | Das Adhikari, Gopal Krushna Chebolu, Rajesh Ravikumar, Ponneri Chandrababu |
| author_facet | Das Adhikari, Gopal Krushna Chebolu, Rajesh Ravikumar, Ponneri Chandrababu |
| author_sort | Das Adhikari, Gopal Krushna |
| collection | PubMed |
| description | [Image: see text] A highly stereo- and regioselective synthesis of the core skeleton of hexahydrobenzo[c]phenanthridine-type alkaloids is reported herein for the first time. A wide range of substrate scope, excellent functional group tolerance, and good to excellent yields were observed. This protocol gives very concise and efficient access to the core skeleton of chelidonine alkaloids as compared to the earlier approaches. |
| format | Online Article Text |
| id | pubmed-7513371 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75133712020-09-25 Regio- and Stereoselective Synthesis of the Core Structure of Hexahydrobenzo[c]phenanthridine Alkaloids via Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation of Cyclic Alkenes with Benzamides Das Adhikari, Gopal Krushna Chebolu, Rajesh Ravikumar, Ponneri Chandrababu ACS Omega [Image: see text] A highly stereo- and regioselective synthesis of the core skeleton of hexahydrobenzo[c]phenanthridine-type alkaloids is reported herein for the first time. A wide range of substrate scope, excellent functional group tolerance, and good to excellent yields were observed. This protocol gives very concise and efficient access to the core skeleton of chelidonine alkaloids as compared to the earlier approaches. American Chemical Society 2020-09-10 /pmc/articles/PMC7513371/ /pubmed/32984725 http://dx.doi.org/10.1021/acsomega.0c03434 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Das Adhikari, Gopal Krushna Chebolu, Rajesh Ravikumar, Ponneri Chandrababu Regio- and Stereoselective Synthesis of the Core Structure of Hexahydrobenzo[c]phenanthridine Alkaloids via Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation of Cyclic Alkenes with Benzamides |
| title | Regio- and Stereoselective Synthesis of the Core Structure
of Hexahydrobenzo[c]phenanthridine Alkaloids via
Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation
of Cyclic Alkenes with Benzamides |
| title_full | Regio- and Stereoselective Synthesis of the Core Structure
of Hexahydrobenzo[c]phenanthridine Alkaloids via
Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation
of Cyclic Alkenes with Benzamides |
| title_fullStr | Regio- and Stereoselective Synthesis of the Core Structure
of Hexahydrobenzo[c]phenanthridine Alkaloids via
Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation
of Cyclic Alkenes with Benzamides |
| title_full_unstemmed | Regio- and Stereoselective Synthesis of the Core Structure
of Hexahydrobenzo[c]phenanthridine Alkaloids via
Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation
of Cyclic Alkenes with Benzamides |
| title_short | Regio- and Stereoselective Synthesis of the Core Structure
of Hexahydrobenzo[c]phenanthridine Alkaloids via
Redox-Neutral Cp*Rh(III)-Catalyzed C–H/N–H Annulation
of Cyclic Alkenes with Benzamides |
| title_sort | regio- and stereoselective synthesis of the core structure
of hexahydrobenzo[c]phenanthridine alkaloids via
redox-neutral cp*rh(iii)-catalyzed c–h/n–h annulation
of cyclic alkenes with benzamides |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513371/ https://www.ncbi.nlm.nih.gov/pubmed/32984725 http://dx.doi.org/10.1021/acsomega.0c03434 |
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