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Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage

Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such dama...

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Detalles Bibliográficos
Autores principales: Ye, Fei, Ning, Jing, Fardous, Zeenath, Katsube, Takanori, Li, Qiang, Wang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513408/
https://www.ncbi.nlm.nih.gov/pubmed/33013253
http://dx.doi.org/10.1177/1559325820962341
Descripción
Sumario:Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation.