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Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage

Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such dama...

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Detalles Bibliográficos
Autores principales: Ye, Fei, Ning, Jing, Fardous, Zeenath, Katsube, Takanori, Li, Qiang, Wang, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513408/
https://www.ncbi.nlm.nih.gov/pubmed/33013253
http://dx.doi.org/10.1177/1559325820962341
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author Ye, Fei
Ning, Jing
Fardous, Zeenath
Katsube, Takanori
Li, Qiang
Wang, Bing
author_facet Ye, Fei
Ning, Jing
Fardous, Zeenath
Katsube, Takanori
Li, Qiang
Wang, Bing
author_sort Ye, Fei
collection PubMed
description Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation.
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spelling pubmed-75134082020-10-01 Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage Ye, Fei Ning, Jing Fardous, Zeenath Katsube, Takanori Li, Qiang Wang, Bing Dose Response Review Radiation damage assessment of the small intestine is important in nuclear accidents or routine radiotherapy of abdominal tumors. This article reviews the clinical symptoms and molecular mechanisms of radiation-induced small intestinal damage and summarizes recent research on biomarkers of such damage. Citrulline is the most promising biomarker for the evaluation of radiation-induced small intestinal damage caused by radiotherapy and nuclear accidents. This article also summarizes the factors influencing plasma citrulline measurement investigated in the latest research, as well as new findings on the concentration of citrulline in saliva and urine after different types of radiation. SAGE Publications 2020-09-22 /pmc/articles/PMC7513408/ /pubmed/33013253 http://dx.doi.org/10.1177/1559325820962341 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Ye, Fei
Ning, Jing
Fardous, Zeenath
Katsube, Takanori
Li, Qiang
Wang, Bing
Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_full Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_fullStr Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_full_unstemmed Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_short Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage
title_sort citrulline, a potential biomarker of radiation-induced small intestine damage
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513408/
https://www.ncbi.nlm.nih.gov/pubmed/33013253
http://dx.doi.org/10.1177/1559325820962341
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