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Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report

Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghan...

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Autores principales: Fickling, Shaun D., Greene, Trevor, Greene, Debbie, Frehlick, Zack, Campbell, Natasha, Etheridge, Tori, Smith, Christopher J., Bollinger, Fabio, Danilov, Yuri, Rizzotti, Rowena, Livingstone, Ashley C., Lakhani, Bimal, D’Arcy, Ryan C. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513585/
https://www.ncbi.nlm.nih.gov/pubmed/33132868
http://dx.doi.org/10.3389/fnhum.2020.00347
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author Fickling, Shaun D.
Greene, Trevor
Greene, Debbie
Frehlick, Zack
Campbell, Natasha
Etheridge, Tori
Smith, Christopher J.
Bollinger, Fabio
Danilov, Yuri
Rizzotti, Rowena
Livingstone, Ashley C.
Lakhani, Bimal
D’Arcy, Ryan C. N.
author_facet Fickling, Shaun D.
Greene, Trevor
Greene, Debbie
Frehlick, Zack
Campbell, Natasha
Etheridge, Tori
Smith, Christopher J.
Bollinger, Fabio
Danilov, Yuri
Rizzotti, Rowena
Livingstone, Ashley C.
Lakhani, Bimal
D’Arcy, Ryan C. N.
author_sort Fickling, Shaun D.
collection PubMed
description Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghanistan. TG continues intensive daily rehabilitation, which recently included the integration of physical therapy (PT) with neuromodulation using translingual neurostimulation (TLNS) to facilitate neuroplasticity. Recent findings with PT + TLNS demonstrated that recovery of motor function occurred beyond conventional time limits, currently extending past 14-years post-injury. To investigate whether PT + TLNS similarly resulted in associated cognitive function improvements, we examined event-related potentials (ERPs) with the brain vital signs framework. In parallel with motor function improvements, brain vital signs detected significant increases in basic attention (as measured by P300 response amplitude) and cognitive processing (as measured by contextual N400 response amplitude). These objective cognitive improvements corresponded with TG’s self-reported improvements, including a noteworthy and consistent reduction in ongoing symptoms of post-traumatic stress disorder (PTSD). The findings provide valuable insight into the potential importance of non-invasive neuromodulation in cognitive rehabilitation, in addition to initial indications for physical rehabilitation.
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spelling pubmed-75135852020-10-30 Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report Fickling, Shaun D. Greene, Trevor Greene, Debbie Frehlick, Zack Campbell, Natasha Etheridge, Tori Smith, Christopher J. Bollinger, Fabio Danilov, Yuri Rizzotti, Rowena Livingstone, Ashley C. Lakhani, Bimal D’Arcy, Ryan C. N. Front Hum Neurosci Human Neuroscience Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghanistan. TG continues intensive daily rehabilitation, which recently included the integration of physical therapy (PT) with neuromodulation using translingual neurostimulation (TLNS) to facilitate neuroplasticity. Recent findings with PT + TLNS demonstrated that recovery of motor function occurred beyond conventional time limits, currently extending past 14-years post-injury. To investigate whether PT + TLNS similarly resulted in associated cognitive function improvements, we examined event-related potentials (ERPs) with the brain vital signs framework. In parallel with motor function improvements, brain vital signs detected significant increases in basic attention (as measured by P300 response amplitude) and cognitive processing (as measured by contextual N400 response amplitude). These objective cognitive improvements corresponded with TG’s self-reported improvements, including a noteworthy and consistent reduction in ongoing symptoms of post-traumatic stress disorder (PTSD). The findings provide valuable insight into the potential importance of non-invasive neuromodulation in cognitive rehabilitation, in addition to initial indications for physical rehabilitation. Frontiers Media S.A. 2020-09-10 /pmc/articles/PMC7513585/ /pubmed/33132868 http://dx.doi.org/10.3389/fnhum.2020.00347 Text en Copyright © 2020 Fickling, Greene, Greene, Frehlick, Campbell, Etheridge, Smith, Bollinger, Danilov, Rizzotti, Livingstone, Lakhani and D’Arcy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Fickling, Shaun D.
Greene, Trevor
Greene, Debbie
Frehlick, Zack
Campbell, Natasha
Etheridge, Tori
Smith, Christopher J.
Bollinger, Fabio
Danilov, Yuri
Rizzotti, Rowena
Livingstone, Ashley C.
Lakhani, Bimal
D’Arcy, Ryan C. N.
Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title_full Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title_fullStr Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title_full_unstemmed Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title_short Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report
title_sort brain vital signs detect cognitive improvements during combined physical therapy and neuromodulation in rehabilitation from severe traumatic brain injury: a case report
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513585/
https://www.ncbi.nlm.nih.gov/pubmed/33132868
http://dx.doi.org/10.3389/fnhum.2020.00347
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