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Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition

In general, a mathematical model that contains many linear/nonlinear differential equations, describing a phenomenon, does not have an explicit hierarchy of system variables. That is, the identification of the fast variables and the slow variables of the system is not explicitly clear. The decomposi...

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Detalles Bibliográficos
Autores principales: Nave, OPhir, Hartuv, Israel, Shemesh, Uziel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513748/
https://www.ncbi.nlm.nih.gov/pubmed/33005495
http://dx.doi.org/10.7717/peerj.10019
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author Nave, OPhir
Hartuv, Israel
Shemesh, Uziel
author_facet Nave, OPhir
Hartuv, Israel
Shemesh, Uziel
author_sort Nave, OPhir
collection PubMed
description In general, a mathematical model that contains many linear/nonlinear differential equations, describing a phenomenon, does not have an explicit hierarchy of system variables. That is, the identification of the fast variables and the slow variables of the system is not explicitly clear. The decomposition of a system into fast and slow subsystems is usually based on intuitive ideas and knowledge of the mathematical model being investigated. In this study, we apply the singular perturbed vector field (SPVF) method to the COVID-19 mathematical model of to expose the hierarchy of the model. This decomposition enables us to rewrite the model in new coordinates in the form of fast and slow subsystems and, hence, to investigate only the fast subsystem with different asymptotic methods. In addition, this decomposition enables us to investigate the stability analysis of the model, which is important in case of COVID-19. We found the stable equilibrium points of the mathematical model and compared the results of the model with those reported by the Chinese authorities and found a fit of approximately 96 percent.
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spelling pubmed-75137482020-09-30 Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition Nave, OPhir Hartuv, Israel Shemesh, Uziel PeerJ Computational Biology In general, a mathematical model that contains many linear/nonlinear differential equations, describing a phenomenon, does not have an explicit hierarchy of system variables. That is, the identification of the fast variables and the slow variables of the system is not explicitly clear. The decomposition of a system into fast and slow subsystems is usually based on intuitive ideas and knowledge of the mathematical model being investigated. In this study, we apply the singular perturbed vector field (SPVF) method to the COVID-19 mathematical model of to expose the hierarchy of the model. This decomposition enables us to rewrite the model in new coordinates in the form of fast and slow subsystems and, hence, to investigate only the fast subsystem with different asymptotic methods. In addition, this decomposition enables us to investigate the stability analysis of the model, which is important in case of COVID-19. We found the stable equilibrium points of the mathematical model and compared the results of the model with those reported by the Chinese authorities and found a fit of approximately 96 percent. PeerJ Inc. 2020-09-21 /pmc/articles/PMC7513748/ /pubmed/33005495 http://dx.doi.org/10.7717/peerj.10019 Text en © 2020 Nave et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Computational Biology
Nave, OPhir
Hartuv, Israel
Shemesh, Uziel
Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title_full Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title_fullStr Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title_full_unstemmed Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title_short Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition
title_sort θ-seihrd mathematical model of covid19-stability analysis using fast-slow decomposition
topic Computational Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513748/
https://www.ncbi.nlm.nih.gov/pubmed/33005495
http://dx.doi.org/10.7717/peerj.10019
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